CAS 145667-75-0

Latanoprost Lactone Diol

Description:

Latanoprost Lactone Diol, with the CAS number 145667-75-0, is a chemical compound that is primarily recognized for its role in ophthalmology, particularly in the treatment of glaucoma and ocular hypertension. It is a derivative of latanoprost, a prostaglandin analog that functions by increasing the outflow of aqueous humor, thereby reducing intraocular pressure. The lactone structure contributes to its stability and bioactivity. Latanoprost Lactone Diol exhibits characteristics typical of prostaglandin analogs, including potent ocular hypotensive effects. It is generally administered as an eye drop formulation. The compound is known for its lipophilicity, which enhances its penetration through biological membranes, facilitating its therapeutic action. Additionally, it may have side effects such as conjunctival hyperemia and changes in iris pigmentation, which are common with prostaglandin therapies. Overall, Latanoprost Lactone Diol is significant in clinical applications for managing eye pressure-related conditions.

Formula: C₁₈H₂₄O₄

InChI: InChI=1/C18H24O4/c19-13(7-6-12-4-2-1-3-5-12)8-9-14-15-10-18(21)22-17(15)11-16(14)20/h1-5,13-17,19-20H,6-11H2/t13-,14+,15+,16+,17-/m0/s1

Synonyms:

• (3Ar,4R,5R,6As)-Hexahydro-5-Hydroxy-4-[(3R)-3-Hydroxy-5-Phenylpentyl]-2H-Cyclopenta[B]Furan-2-One
• (3Ar,4R,5R,6As)-5-Hydroxy-4-((3R)-3-Hydroxy-5-Phenylpentyl)Hexahydrocyclopenta[B]Furan-2-One
• Lp-Diol (Lt-Di)(Latanprost)
• (3Ar,4R,5R,6As)-5-Hydroxy-4-[(3R)-3-Hydroxy-5-Phenylpentyl]Hexahydro-2H-Cyclopenta[B]Furan-2-One
• 2H-Cyclopenta[B]Furan-2-One, Hexahydro-5-Hydroxy-4-[(3R)-3-Hydroxy-5-Phenylpentyl]-, (3Ar,4R,5R,6As)-

2H-Cyclopenta[b]furan-2-one, hexahydro-5-hydroxy-4-[(3R)-3-hydroxy-5-phenylpentyl]-, (3aR,4R,5R,6aS)-

CAS: 145667-75-0

Formula: C₁₈H₂₄O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 304.3808

Ref: IN-DA001D9S

(3aR,4R,5R,6aS)-5-Hydroxy-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-one

CAS: 145667-75-0

(3aR,4R,5R,6aS)-5-Hydroxy-4-((R)-3-hydroxy-5-phenylpentyl)hexahydro-2H-cyclopenta[b]furan-2-one

Purity: 95%

Molecular weight: 304.39g/mol

Ref: 54-OR1051489

Latanoprost Lactone Diol

CAS: 145667-75-0

Formula: C₁₈H₂₄O₄

Color and Shape: White To Off-White Solid

Molecular weight: 304.39

Ref: 4Z-L-3227

Latanoprost lactone diol

CAS: 145667-75-0

Latanoprost lactone diol, a key intermediate for synthesizing Latanoprost (a prostaglandin F2α analogue), lowers IOP by activating FP receptors.

Formula: C₁₈H₂₄O₄

Purity: 98%

Color and Shape: White Or Almost White Crystalline Powder

Molecular weight: 304.38

Ref: TM-T11821

(3aR,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(3R)-3-hydroxy-5-phenylpentyl]2H-cyclopenta[b]furan-2-one

Controlled Product

CAS: 145667-75-0

Applications (3aR,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(3R)-3-hydroxy-5-phenylpentyl]2H-cyclopenta[b]furan-2-one is phenyl-substituted prostaglandin and a potent and selective antiglaucoma agents.
References Bahram, R., et al.: J. Med. Chem., 36, 2242 (1993); Resul, B., et al.: J. Med. Chem., 36, 243 (1993);

Formula: C₁₈H₂₄O₄

Color and Shape: Neat

Molecular weight: 304.38

Ref: TR-H294065

Latanoprost Lactone Diol

CAS: 145667-75-0

Formula: C₁₈H₂₄O₄

Molecular weight: 304.39

Ref: ST-EA-CP-L32024