CAS 145733-36-4: Tasosartan
Description:Tasotsartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It belongs to the class of medications known as sartans, which work by blocking the action of angiotensin II, a hormone that constricts blood vessels and increases blood pressure. The chemical formula of tasosartan reflects its complex structure, which includes a biphenyl moiety and a carboxylic acid group, contributing to its pharmacological activity. It is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. Tasosartan exhibits good bioavailability and is metabolized in the liver, with its metabolites contributing to its antihypertensive effects. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances, although it is generally well-tolerated. As with other medications in its class, tasosartan is contraindicated in pregnancy due to potential risks to fetal development. Overall, tasosartan represents an important option in the management of high blood pressure, contributing to cardiovascular health.
Formula:C23H21N7O
InChI:InChI=1/C23H21N7O/c1-14-18-11-12-21(31)30(23(18)25-15(2)24-14)13-16-7-9-17(10-8-16)19-5-3-4-6-20(19)22-26-28-29-27-22/h3-10H,11-13H2,1-2H3,(H,26,27,28,29)
InChI key:InChIKey=ADXGNEYLLLSOAR-UHFFFAOYSA-N
SMILES:O=C1N(C2=NC(=NC(=C2CC1)C)C)CC=3C=CC(=CC3)C=4C=CC=CC4C5=NN=NN5
- Synonyms:
- 2,4-Dimethyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[6,5-d]pyrimidin-7-one
- 2,4-dimethyl-8-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one
![Pyrido[2,3-d]pyrimidin-7(6H)-one, 5,8-dihydro-2,4-dimethyl-8-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl…](https://static.cymitquimica.com/products/IN/thumb/DA001DDC.jpg)
