CAS 145733-36-4

Tasosartan

Description:

Tasotsartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It belongs to the class of medications known as sartans, which work by blocking the action of angiotensin II, a hormone that constricts blood vessels and increases blood pressure. The chemical formula of tasosartan reflects its complex structure, which includes a biphenyl moiety and a carboxylic acid group, contributing to its pharmacological activity. It is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. Tasosartan exhibits good bioavailability and is metabolized in the liver, with its metabolites contributing to its antihypertensive effects. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances, although it is generally well-tolerated. As with other medications in its class, tasosartan is contraindicated in pregnancy due to potential risks to fetal development. Overall, tasosartan represents an important option in the management of high blood pressure, contributing to cardiovascular health.

Formula: C₂₃H₂₁N₇O

InChI: InChI=1/C23H21N7O/c1-14-18-11-12-21(31)30(23(18)25-15(2)24-14)13-16-7-9-17(10-8-16)19-5-3-4-6-20(19)22-26-28-29-27-22/h3-10H,11-13H2,1-2H3,(H,26,27,28,29)

InChI key: InChIKey=ADXGNEYLLLSOAR-UHFFFAOYSA-N

SMILES: C(N1C=2C(CCC1=O)=C(C)N=C(C)N2)C3=CC=C(C=C3)C4=C(C=CC=C4)C=5NN=NN5

Synonyms:

• 2,4-Dimethyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[6,5-d]pyrimidin-7-one
• 2,4-dimethyl-8-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one

Pyrido[2,3-d]pyrimidin-7(6H)-one, 5,8-dihydro-2,4-dimethyl-8-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

CAS: 145733-36-4

Formula: C₂₃H₂₁N₇O

Purity: 99%

Color and Shape: Solid

Molecular weight: 411.4591

Ref: IN-DA001DDC

Tasosartan

CAS: 145733-36-4

Formula: C₂₃H₂₁N₇O

Molecular weight: 411.46

Ref: 7W-GP7394

Tasosartan

CAS: 145733-36-4

Tasosartan

Purity: ≥98%

Molecular weight: 411.46g/mol

Ref: 54-BUP09514

8-((2'-(1H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-2,4-Dimethyl-5,6-Dihydropyrido[2,3-D]Pyrimidin-7(8H)-One

CAS: 145733-36-4

8-((2'-(1H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-2,4-Dimethyl-5,6-Dihydropyrido[2,3-D]Pyrimidin-7(8H)-One

Purity: 95%

Molecular weight: 411.46g/mol

Ref: 54-OR1023991

Tasosartan

CAS: 145733-36-4

Tasosartan (WAY-ANA 756) is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM).

Formula: C₂₃H₂₁N₇O

Purity: 98.2% - 98.9%

Color and Shape: Solid

Molecular weight: 411.46

Ref: TM-T7797

Tasosartan

CAS: 145733-36-4

Tasosartan is a drug that belongs to the group of angiotensin II receptor antagonists. It is used to treat high blood pressure, congestive heart failure, and to prevent kidney and eye damage caused by diabetes. Tasosartan inhibits the action of an enzyme called angiotensin-converting enzyme (ACE) in the body, which leads to reduced levels of the hormone angiotensin II. This lowers blood pressure by reducing the amount of sodium and water in the body, which decreases blood volume. Tasosartan has been shown to be effective against infectious diseases such as Helicobacter pylori, Mycobacterium tuberculosis, and Chlamydia pneumoniae infections. The drug also has anti-inflammatory effects because it blocks inflammatory cytokines such as IL-1β and TNFα production.

Formula: C₂₃H₂₁N₇O

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 411.46 g/mol

Ref: 3D-FT161252

Tasosartan-d4

Controlled Product

CAS: 145733-36-4

Formula: C₂₃H₁₇D₄N₇O

Color and Shape: Neat

Molecular weight: 415.48

Ref: TR-T007782

Tasosartan

Controlled Product

CAS: 145733-36-4

Applications Tasosartan is an angiotensin II receptor antagonist.
References Krovat, E., et al.: J. Med. Chem., 46, 716 (2003); Kurup, A., et al.: Chem. Rev., 101, 2727 (2001)

Formula: C₂₃H₂₁N₇O

Color and Shape: Neat

Molecular weight: 411.46

Ref: TR-T007780