CAS 145781-92-6

Goserelin acetate

Description:

Goserelin acetate is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH), primarily used in the treatment of hormone-sensitive conditions such as prostate cancer and endometriosis. It functions as a GnRH agonist, initially stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which subsequently leads to a decrease in sex hormone production through downregulation of GnRH receptors. This results in reduced levels of testosterone and estrogen, making it effective in managing hormone-dependent diseases. Goserelin acetate is typically administered via subcutaneous implant, providing a sustained release of the active substance over time. The compound is characterized by its ability to modulate hormonal pathways, its relatively low molecular weight, and its stability under physiological conditions. Side effects may include hot flashes, decreased libido, and potential impacts on bone density, necessitating careful monitoring during treatment. Overall, Goserelin acetate plays a crucial role in endocrine therapy, showcasing the therapeutic potential of peptide-based drugs in oncology and gynecology.

Formula: C₆₁H₈₈N₁₈O₁₆

InChI: InChI=1/C59H84N18O14.C2H4O2/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38;1-2(3)4/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90);1H3,(H,3,4)/t38-,39-,40-,41-,42-,43-,44-,45+,46-;/m0./s1

Synonyms:

• Pyr-His-Trp-Ser-Tyr-D-Ser(Tbu)-Leu-Arg-Pro-Azagly-Nh2
• [(T-Bu)Dser6, (Aza)Gly10]-Lh-Rh
• [(T-Bu)Dser6, (Aza)Gly10]-Luteinizing Hormone-Releasing Hormone
• Glp-His-Trp-Ser-Tyr-D-Ser(Tbu)-Leu-Arg-Pro-Aza-Gly-Nh2
• (D-Ser(Tbu)6,Azagly10)-Lhrh
• (D-Ser(tBu)6,Azagly10)-LHRH acetate salt
• Goserelin HCl
• Goserelin Hcl[Pyr-His-Trp-Ser-Tyr-D-Ser(T-Bu)-Leu-Arg-Pro-Azagly-Nh2]
• 5-oxoprolylhistidyl-N-[18,18-diamino-7-(tert-butoxymethyl)-13-({2-[(2-carbamoylhydrazinyl)carbonyl]pyrrolidin-1-yl}carbonyl)-4-(4-hydroxybenzyl)-1-(hydroxymethyl)-10-(2-methylpropyl)-2,5,8,11-tetraoxo-3,6,9,12,17-pentaazaoctadec-17-en-1-yl]tryptophanamide acetate (1:1)
• (2S)-N-[(2S,5S,8S,11S,14R,17S,20S)-25-amino-14-(tert-butoxymethyl)-20-({(2S)-2-[(2-carbamoylhydrazinyl)carbonyl]pyrrolidin-1-yl}carbonyl)-11-(4-hydroxybenzyl)-8-(hydroxymethyl)-1-(1H-imidazol-4-yl)-25-imino-5-(1H-indol-3-ylmethyl)-17-(2-methylpropyl)-3,6,9,12,15,18-hexaoxo-4,7,10,13,16,19,24-heptaazapentacosan-2-yl]-5-oxopyrrolidine-2-carboxamide acetate (1:1) (non-preferred name)

(D-Ser(tBu)⁶,Azagly¹⁰)-LHRH

CAS: 145781-92-6

Goserelin acetate, a synthetic peptide analog of LHRH, is used in the treatment of prostate cancer, advanced breast cancer and in the management of endometriosis. CAS Number (Goserelin net): 65807-02-5.

Formula: C₅₉H₈₄N₁₈O₁₄

Purity: 99.6%

Color and Shape: White

Molecular weight: 1269.43

Ref: 01-4038252

GOSERELIN VALIDATION MIXTURE CRS

CAS: 145781-92-6

GOSERELIN VALIDATION MIXTURE CRS

Formula: C₅₉H₈₄N₁₈O₁₄

Molecular weight: 1269.411

Ref: 41-Y0000194

GOSERELIN CRS

CAS: 145781-92-6

GOSERELIN CRS

Formula: C₅₉H₈₄N₁₈O₁₄

Molecular weight: 1269.411

Ref: 41-Y0000125

GOSERELIN FOR NMR IDENTIFICATION CRS

CAS: 145781-92-6

GOSERELIN FOR NMR IDENTIFICATION CRS

Formula: C₅₉H₈₄N₁₈O₁₄

Molecular weight: 1269.411

Ref: 41-Y0001473

Goserelin Acetate

CAS: 145781-92-6

Polypeptide, protein and glycoprotein hormones, their derivatives and structural analogues, nesoi

Formula: C₅₉H₈₄N₁₈O₁₄·xC₂H₄O₂

Color and Shape: White Off-White Powder

Molecular weight: 1268.64144

Ref: 45-1297205

Goserelin acetate

CAS: 145781-92-6

Formula: C₆₁H₈₈N₁₈O₁₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 1329.4624

Ref: IN-DA001DEH

Goserelin acetate

CAS: 145781-92-6

Formula: C₅₉H₈₄N₁₈O₁₄

Purity: ≥ 98.0%

Color and Shape: White powder

Molecular weight: 1269.41

Ref: 7W-GK2378

Goserelin acetate

CAS: 145781-92-6

Goserelin acetate

Purity: ≥98%

Molecular weight: 1329.46g/mol

Ref: 54-BUP05896

Goserelin acetate

CAS: 145781-92-6

Goserelin acetate (Fertilan) is a synthetic long-acting agonist of gonadotropin-releasing hormone, used in treatments of cancer.

Formula: C₆₁H₈₈N₁₈O₁₆

Purity: 99.77% - >99.99%

Color and Shape: White Crystalline Powder

Molecular weight: 1329.46

Ref: TM-T4102

Goserelin Acetate RS

CAS: 145781-92-6

Color and Shape: White Solid Powder

Ref: 2K-1056500021

Goserelin acetate

Controlled Product

CAS: 145781-92-6

LHRH analog; GnRH receptor agonist; antineoplastic

Formula: C₅₉H₈₄N₁₈O₁₄·xH₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1269.41

Ref: 3D-FG44023