CAS 145808-47-5

margatoxin scorpion

Description:

Margatoxin, a neurotoxic peptide derived from the venom of the scorpion species Centruroides margaritatus, is known for its potent effects on ion channels, particularly voltage-gated potassium channels. This 38-amino acid peptide exhibits a high affinity for these channels, leading to prolonged depolarization of neurons, which can result in paralysis or other neurological effects in prey. Margatoxin is characterized by its stability in various conditions, making it a subject of interest in pharmacological research, particularly for its potential applications in pain management and neurobiology. The structure of margatoxin includes several disulfide bonds that contribute to its stability and biological activity. Its unique mechanism of action and specificity for certain ion channels make it a valuable tool for studying cellular excitability and signaling pathways. Additionally, research into margatoxin may provide insights into the development of novel therapeutic agents targeting ion channel-related disorders.

Formula: C₁₇₈H₂₈₆N₅₂O₅₀S₇

Synonyms:

• Margatoxin, Centruroides margaritatus
• H-Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His-OH (Disulfide bonds between Cys7 and Cys29/Cys13 and Cys34/ Cys17 and Cys36)
• Margatoxin, Recomb.
• Margatoxin

L-Histidine, L-threonyl-L-isoleucyl-L-isoleucyl-L-asparaginyl-L-valyl-L-lysyl-L-cysteinyl-L-threonyl-L-seryl-L-prolyl-L-lysyl-L-glutaminyl-L-cysteinyl-L-leucyl-L-prolyl-L-prolyl-L-cysteinyl-L-lysyl-L-alanyl-L-glutaminyl-L-phenylalanylglycyl-L-glutaminyl-L-seryl-L-alanylglycyl-L-alanyl-L-lysyl-L-cysteinyl-L-methionyl-L-asparaginylglycyl-L-lysyl-L-cysteinyl-L-lysyl-L-cysteinyl-L-tyrosyl-L-prolyl-, cyclic (7→29),(13→34),(17→36)-tris(disulfide)

CAS: 145808-47-5

Formula: C₅₇H₆₈N₅O₈PSi

Purity: 98.67%

Molecular weight: 1010.2378

Ref: IN-DA001DEX

Margatoxin

CAS: 145808-47-5

KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx & NO in endothelial cells.

Formula: C₁₇₈H₂₈₆N₅₂O₅₀S₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 4178.96

Ref: TM-TP2004

Margatoxin

CAS: 145808-47-5

Formula: C₁₇₈H₂₈₆N₅₂O₅₀S₇

Molecular weight: 4178.95

Ref: 7W-GK1890

Margatoxin

CAS: 145808-47-5

Margatoxin is a research tool that has been shown to activate the nicotinic acetylcholine receptor. It binds to the ligand-binding site of the receptor and blocks ion channel activity. Margatoxin is a small molecule with high purity that can be used as a tool to study protein interactions and biological functions. This compound is also an inhibitor of peptide binding, which can be used in pharmacology studies.

Formula: C₁₇₈H₂₈₆N₅₂O₅₀S₇

Purity: Min. 95%

Molecular weight: 4,178.9 g/mol

Ref: 3D-PAR-4290-S

Margatoxin

CAS: 145808-47-5

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Formula: C₁₇₈H₂₈₆N₅₂O₅₀S₇

Purity: Min. 95%

Molecular weight: 4,178.96 g/mol

Ref: 3D-FM108623