CAS 145819-92-7

[[[(2R,5S)-5-(4-amino-5-fluoro-2,6-dioxo-3H-pyrimidin-1-yl)-1,3-oxathi olan-2-yl]methyl-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphon ic acid

Description:

The chemical substance with the name "[[[(2R,5S)-5-(4-amino-5-fluoro-2,6-dioxo-3H-pyrimidin-1-yl)-1,3-oxathiolan-2-yl]methyl-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid" and CAS number 145819-92-7 is a complex organic compound characterized by its unique structural features, including a pyrimidine ring, oxathiolane moiety, and multiple phosphoryl groups. This compound exhibits properties typical of phosphonic acids, such as potential acidity and reactivity due to the presence of phosphonate functional groups. The fluorine and amino substituents on the pyrimidine ring may influence its biological activity, potentially enhancing its interaction with biological targets. The stereochemistry indicated by the (2R,5S) configuration suggests specific spatial arrangements that could affect the compound's pharmacological properties. Overall, this substance may have applications in medicinal chemistry, particularly in the development of antiviral or antibacterial agents, given the structural motifs commonly associated with bioactive compounds. Further studies would be necessary to elucidate its specific biological activities and potential therapeutic uses.

Formula: C₈H₁₃FN₃O₁₂P₃S

InChI: InChI=1/C8H13FN3O12P3S/c9-5-6(10)11-8(14)12(7(5)13)3-2-28-4(22-3)1-25(15,16)23-27(20,21)24-26(17,18)19/h3-4H,1-2,10H2,(H,11,14)(H,15,16)(H,20,21)(H2,17,18,19)/t3-,4+/m0/s1

Synonyms:

• 5-Fluoro-1-(2-Hydroxymethyl)-1,3-Oxathiolane-5-Yl-Cytidine-5'-Triphosphate
• [(2R,5S)-5-(4-amino-5-fluoro-2,6-dioxo-3H-pyrimidin-1-yl)-1,3-oxathiolan-2-yl]methyl-(hydroxy-phosphonooxy-phosphoryl)oxy-phosphinic acid

Emtricitabine Triphosphate Triethylammonium Salt

Controlled Product

CAS: 145819-92-7

Stability Hygroscopic
Applications Emtricitabine Triphosphate Triethylammonium Salt is a metabolite of (-)-Emtricitabine (E525000).
References Barditch-Crovo, P., et al.: Antimicrob. Agents Chemother., 45, 2733 (2001); Ray, A., et al.: Antivir .Ther., 10, 451 (2005); Borroto-Esoda, K., et al.: Antivir. Ther., 11, 377 (2006)

Formula: C₈H₁₃FN₃O₁₂P₃S•3(C₆H₁₅N)

Color and Shape: Neat

Molecular weight: 487.19101193

Ref: TR-E525075

(-)-Emtricitabine triphosphate sodium salt

CAS: 145819-92-7

Emtricitabine is a nucleoside reverse transcriptase inhibitor with activity against human immunodeficiency virus and hepatitis B virus

Formula: C₈H₉FN₃Na₄O₁₂P₃S

Purity: Min. 95%

Molecular weight: 575.11 g/mol

Ref: 3D-NE182496

Emtricitabine triphosphate

CAS: 145819-92-7

Emtricitabine triphosphate is an active metabolite of Emtricitabine, a drug for HIV/HBV that inhibits reverse transcriptase.

Formula: C₈H₁₃FN₃O₁₂P₃S

Color and Shape: Solid

Molecular weight: 487.19

Ref: TM-T70596