CAS 145821-59-6: Tiagabine hydrochloride

Description: Tiagabine hydrochloride is a pharmaceutical compound primarily used as an anticonvulsant in the treatment of epilepsy and as an adjunct therapy for anxiety disorders. It functions as a selective inhibitor of the neurotransmitter gamma-aminobutyric acid (GABA) reuptake, thereby increasing GABA levels in the synaptic cleft and enhancing inhibitory neurotransmission. This mechanism contributes to its efficacy in controlling seizures and alleviating anxiety symptoms. The substance appears as a white to off-white crystalline powder and is soluble in water and methanol, which facilitates its formulation in various dosage forms. Tiagabine hydrochloride is typically administered orally, and its pharmacokinetics involve hepatic metabolism, primarily through the cytochrome P450 system. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances. As with any medication, it is essential to use tiagabine under medical supervision to monitor for potential interactions and adverse effects. Overall, tiagabine hydrochloride represents a significant therapeutic option for managing certain neurological and psychiatric conditions.

Formula: C₂₀H₂₅NO₂S₂·ClH

InChI: InChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1

InChI key: InChIKey=YUKARLAABCGMCN-PKLMIRHRSA-N

SMILES: Cl.O=C(O)C1CN(CCC=C(C=2SC=CC2C)C=3SC=CC3C)CCC1

Synonyms:

• (3R)-1-[4,4-Bis(3-methylthien-2-yl)-3-butenyl]piperidine-3-carboxylic acid hydrochloride
• (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-en-1-yl]piperidine-3-carboxylic acid hydrochloride
• (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid hydrochloride
• (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl]piperidine-3-carboxylic acid hydrochloride (1:1)
• 3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-, hydrochloride (1:1), (3R)-
• 3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-, hydrochloride, (3R)-
• 3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-, hydrochloride, (R)-
• Abbott 70569 hydrochloride
• Abbott 70569.1
• Abt 569
• Gabitril
• Nnc 05-0328
• No 05-0328
• Tiabex
• Tiagabine Hydrochloride

Tiagabine Hydrochloride

CAS: 145821-59-6

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

• Formula: C₂₀H₂₅NO₂S₂·HCl
• Color and Shape: White Crystalline Powder
• Molecular weight: 375.13267

3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-, hydrochloride (1:1), (3R)-

CAS: 145821-59-6

• Formula: C₂₀H₂₆ClNO₂S₂
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 412.0089

Tiagabine hydrochloride

CAS: 145821-59-6

• Formula: C₂₀H₂₅NO₂S₂·xHCl
• Molecular weight: 375.55 (free base b

Tiagabine HCl

CAS: 145821-59-6

• Formula: C₂₀H₂₅NO₂S₂·HCl
• Color and Shape: Field Gray Solid
• Molecular weight: 375.56 36.46

Tiagabine Hydrochloride

CAS: 145821-59-6

• Formula: C₂₀H₂₅NO₂S₂·ClH
• Color and Shape: Neat
• Molecular weight: 412.01

Tiagabine hydrochloride

CAS: 145821-59-6

Tiagabine hydrochloride, a nipecotic acid derivative, is an anticonvulsant and selective GABA reuptake inhibitor.

• Formula: C₂₀H₂₅NO₂S₂·HCl
• Purity: 99.09% - 99.77%
• Color and Shape: White To Off-White Solid
• Molecular weight: 412.01

Tiagabine Hydrochloride

CAS: 145821-59-6

Applications Tiagabine Hydrochloride is a GABA uptake inhibitor and an anticonvulsant (1,2,3). It is used …

• Formula: C₂₀H₂₅NO₂S₂·ClH
• Color and Shape: Neat
• Molecular weight: 412.01

Tiagabine hydrochloride

CAS: 145821-59-6

GABA reuptake inhibitor

• Formula: C₂₀H₂₅NO₂S₂•HCl
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 412.01 g/mol