CAS 145821-59-6

Tiagabine hydrochloride

Description:

Tiagabine hydrochloride is a pharmaceutical compound primarily used as an anticonvulsant in the treatment of epilepsy and as an adjunct therapy for anxiety disorders. It functions as a selective inhibitor of the neurotransmitter gamma-aminobutyric acid (GABA) reuptake, thereby increasing GABA levels in the synaptic cleft and enhancing inhibitory neurotransmission. This mechanism contributes to its efficacy in controlling seizures and alleviating anxiety symptoms. The substance appears as a white to off-white crystalline powder and is soluble in water and methanol, which facilitates its formulation in various dosage forms. Tiagabine hydrochloride is typically administered orally, and its pharmacokinetics involve hepatic metabolism, primarily through the cytochrome P450 system. Common side effects may include dizziness, fatigue, and gastrointestinal disturbances. As with any medication, it is essential to use tiagabine under medical supervision to monitor for potential interactions and adverse effects. Overall, tiagabine hydrochloride represents a significant therapeutic option for managing certain neurological and psychiatric conditions.

Formula: C₂₀H₂₅NO₂S₂·ClH

InChI: InChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1

InChI key: InChIKey=YUKARLAABCGMCN-PKLMIRHRSA-N

SMILES: C(=CCCN1C[C@H](C(O)=O)CCC1)(C2=C(C)C=CS2)C3=C(C)C=CS3.Cl

Synonyms:

• (3R)-1-[4,4-Bis(3-methylthien-2-yl)-3-butenyl]piperidine-3-carboxylic acid hydrochloride
• (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-en-1-yl]piperidine-3-carboxylic acid hydrochloride
• (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid hydrochloride
• (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl]piperidine-3-carboxylic acid hydrochloride (1:1)
• 3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-, hydrochloride (1:1), (3R)-
• 3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-, hydrochloride, (3R)-
• 3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-, hydrochloride, (R)-
• Abbott 70569 hydrochloride
• Abbott 70569.1
• Abt 569
• Gabitril
• Nnc 05-0328
• No 05-0328
• Tiabex

Tiagabine Hydrochloride 1.0 mg/ml in Methanol (as free base)

CAS: 145821-59-6

Color and Shape: Single Solution

Ref: 61-AMP1029.00-01

Tiagabine Hydrochloride

CAS: 145821-59-6

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₂₀H₂₅NO₂S₂·HCl

Color and Shape: White Crystalline Powder

Molecular weight: 375.13267

Ref: 45-1667280

3-Piperidinecarboxylic acid, 1-[4,4-bis(3-methyl-2-thienyl)-3-buten-1-yl]-, hydrochloride (1:1), (3R)-

CAS: 145821-59-6

Formula: C₂₀H₂₆ClNO₂S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 412.0089

Ref: IN-DA001DFU

Tiagabine hydrochloride

CAS: 145821-59-6

Tiagabine hydrochloride

Purity: ≥98%

Molecular weight: 412.01g/mol

Ref: 54-BUP11025

Tiagabine Hydrochloride

CAS: 145821-59-6

Tiagabine Hydrochloride

Purity: 98%

Molecular weight: 412g/mol

Ref: 54-OR1024328

Tiagabine hydrochloride

CAS: 145821-59-6

Formula: C₂₀H₂₅NO₂S₂·xHCl

Molecular weight: 375.55 (free base b

Ref: 7W-GP8668

Tiagabine HCl

CAS: 145821-59-6

Formula: C₂₀H₂₅NO₂S₂·HCl

Color and Shape: Field Gray Solid

Molecular weight: 375.56 36.46

Ref: 4Z-T-914

Tiagabine Hydrochloride

Controlled Product

CAS: 145821-59-6

Formula: C₂₀H₂₅NO₂S₂·ClH

Color and Shape: Neat

Molecular weight: 412.01

Ref: 86-MM1029.00

Tiagabine hydrochloride

CAS: 145821-59-6

Tiagabine hydrochloride, a nipecotic acid derivative, is an anticonvulsant and selective GABA reuptake inhibitor.

Formula: C₂₀H₂₅NO₂S₂·HCl

Purity: 99.09% - 99.77%

Color and Shape: White To Off-White Solid

Molecular weight: 412.01

Ref: TM-T7000

Tiagabine hydrochloride

Controlled Product

CAS: 145821-59-6

GABA reuptake inhibitor

Formula: C₂₀H₂₅NO₂S₂•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 412.01 g/mol

Ref: 3D-FT28261

Tiagabine Hydrochloride

Controlled Product

CAS: 145821-59-6

Applications Tiagabine Hydrochloride is a GABA uptake inhibitor and an anticonvulsant (1,2,3). It is used to treat epilepsy, anxiety disorders, and panic disorder. Neuroprotective & Neuroresearch Product.
References (1) Andersen, K.E., et al.: J. Med. Chem., 36, 1716 (1993)(2) Fangold, C.L., et al.: Exp. Neurology, 126, 225 (1994) (3) Bauer, J., et al.: J. Epilepsy, 8, 83 (1995)

Formula: C₂₀H₂₅NO₂S₂·ClH

Color and Shape: Neat

Molecular weight: 412.01

Ref: TR-T436400