CAS 145918-75-8

Troxacitabine

Description:

Troxacitabine is a synthetic nucleoside analog that exhibits antitumor properties, primarily used in cancer therapy. It is characterized by its structural similarity to natural nucleosides, which allows it to interfere with DNA synthesis and repair mechanisms in rapidly dividing cancer cells. Troxacitabine functions as a cytotoxic agent, inhibiting the activity of DNA polymerases and ultimately leading to cell death. Its mechanism of action involves incorporation into DNA, resulting in chain termination during replication. The compound is known for its potential effectiveness against various types of cancers, including hematological malignancies and solid tumors. Troxacitabine has been studied in clinical trials to evaluate its efficacy and safety profile, with a focus on optimizing dosing regimens and minimizing side effects. As a member of the class of compounds known as nucleoside analogs, it represents a significant area of research in the development of targeted cancer therapies. Its unique properties and mechanisms make it a valuable candidate in the ongoing search for effective cancer treatments.

Formula: C₈H₁₁N₃O₄

InChI: InChI=1/C8H11N3O4/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6?,7-/m0/s1

InChI key: InChIKey=RXRGZNYSEHTMHC-BQBZGAKWSA-N

SMILES: O=C1N([C@H]2O[C@@H](CO)OC2)C=CC(N)=N1

Synonyms:

• (-)-Bch 204
• (-)-OccC
• 2(1H)-Pyrimidinone, 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-
• 2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-dioxolan-4-yl]-, (2S-cis)-
• 4-Amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-2(1H)-pyrimidinone
• 4-amino-1-[(2S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2(1H)-one
• <span class="text-smallcaps">L</span>-OddC
• Bch 4556
• Spd 758
• Troxacitabine,2(1H)-Pyrimidinone, 4-Amino-1-(2-(Hydroxymethyl)-1,3-Dioxolan-4-Yl)-, (2S-Cis)-
• Troxatyl
• α-<span class="text-smallcaps">L</span>-Dioxolane-C
• 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-1,2-dihydropyrimidin-2-one
• 4-Amino-1-[(2S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one
• 4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-one
• Lamivudine EP Impurity I
• Troxacitabine (SGX-145)
• Lamivudine Impurity I
• (Troxacitabine)
• CS-150
• α-L-Dioxolane-C
• Lamivudine EP Impurity I (Troxacitabine)
• L-Oddc

2(1H)-Pyrimidinone, 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-

CAS: 145918-75-8

Formula: C₈H₁₁N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 213.1906

Ref: IN-DA001DIE

4-Amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-one

CAS: 145918-75-8

4-Amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-one

Purity: 98%

Molecular weight: 213.19g/mol

Ref: 54-OR1074839

Lamivudine EP Impurity I (Troxacitabine)

CAS: 145918-75-8

Formula: C₈H₁₁N₃O₄

Color and Shape: White To Off-White Solid

Molecular weight: 213.19

Ref: 4Z-L-2011

Troxacitabine

CAS: 145918-75-8

Formula: C₈H₁₁N₃O₄

Molecular weight: 213.19

Ref: 7W-GN9928

Troxacitabine

CAS: 145918-75-8

Purity: 97%

Molecular weight: 213.1929932

Ref: 10-F622816

Troxacitabine

Controlled Product

CAS: 145918-75-8

Stability Hygroscopic
Applications Troxacitabine is a nucleoside analogue with potential anticancer activity. Troxacitabine have been studied in patients with refractory lymphoproliferative diseases.
References Robak, T., et al.: Curr. Med. Chem., 18, 638 (2011); Kornblau, S.M., et al.: Clin. Cancer. Res., 16, 3721 (2010);

Formula: C₈H₁₁N₃O₄

Color and Shape: Neat

Molecular weight: 213.19

Ref: TR-T805580

Troxacitabine

CAS: 145918-75-8

Troxacitabine is a nucleoside analog that inhibits DNA synthesis by selectively blocking the function of DNA polymerase. It has been shown to have potent antitumor activity in mouse tumor models and in a human breast cancer xenograft model. Troxacitabine has also been shown to inhibit the proliferation of renal cell cancer cells and induce apoptosis in these cells, as well as reduce the viability of cancer cells from other tumor types. Troxacitabine has also been shown to have an effect on body mass index and hematologic response, although it is not currently approved for use in humans.

Formula: C₈H₁₁N₃O₄

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 213.19 g/mol

Ref: 3D-NT29825

Lamivudine EP Impurity I

CAS: 145918-75-8

Formula: C₈H₁₁N₃O₄

Molecular weight: 213.19

Ref: ST-EA-CP-L3009

Troxacitabine

CAS: 145918-75-8

Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia (AML). In comparison with gemcitabine, troxacitabine was equally active against MiaPaCa and was more efficacious against Panc-01.

Formula: C₈H₁₁N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 213.19

Ref: TM-T17175