CAS 145918-75-8: Troxacitabine

Description: Troxacitabine is a synthetic nucleoside analog that exhibits antitumor properties, primarily used in cancer therapy. It is characterized by its structural similarity to natural nucleosides, which allows it to interfere with DNA synthesis and repair mechanisms in rapidly dividing cancer cells. Troxacitabine functions as a cytotoxic agent, inhibiting the activity of DNA polymerases and ultimately leading to cell death. Its mechanism of action involves incorporation into DNA, resulting in chain termination during replication. The compound is known for its potential effectiveness against various types of cancers, including hematological malignancies and solid tumors. Troxacitabine has been studied in clinical trials to evaluate its efficacy and safety profile, with a focus on optimizing dosing regimens and minimizing side effects. As a member of the class of compounds known as nucleoside analogs, it represents a significant area of research in the development of targeted cancer therapies. Its unique properties and mechanisms make it a valuable candidate in the ongoing search for effective cancer treatments.

Formula: C₈H₁₁N₃O₄

InChI: InChI=1S/C8H11N3O4/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7-/m0/s1

InChI key: InChIKey=RXRGZNYSEHTMHC-BQBZGAKWSA-N

SMILES: O=C1N=C(N)C=CN1C2OC(OC2)CO

Synonyms:

• (-)-Bch 204
• (-)-OccC
• 2(1H)-Pyrimidinone, 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-
• 2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-dioxolan-4-yl]-, (2S-cis)-
• 4-Amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-2(1H)-pyrimidinone
• 4-amino-1-[(2S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2(1H)-one
• <span class="text-smallcaps">L</span>-OddC
• Bch 4556
• Spd 758
• Troxacitabine,2(1H)-Pyrimidinone, 4-Amino-1-(2-(Hydroxymethyl)-1,3-Dioxolan-4-Yl)-, (2S-Cis)-
• Troxatyl
• α-<span class="text-smallcaps">L</span>-Dioxolane-C

Troxacitabine

CAS: 145918-75-8

Troxacitabine, a DNA polymerase inhibitor, is potentially used for the treatment of acute myeloid leukemia …

• Formula: C₈H₁₁N₃O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 213.19

2(1H)-Pyrimidinone, 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-

CAS: 145918-75-8

• Formula: C₈H₁₁N₃O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 213.1906

Troxacitabine

CAS: 145918-75-8

• Formula: C₈H₁₁N₃O₄
• Molecular weight: 213.19

Lamivudine EP Impurity I (Troxacitabine)

CAS: 145918-75-8

• Formula: C₈H₁₁N₃O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 213.19

Troxacitabine

CAS: 145918-75-8

Stability Hygroscopic Applications Troxacitabine is a nucleoside analogue with potential anticancer activity. Troxacitabine have been …

• Formula: C₈H₁₁N₃O₄
• Color and Shape: Neat
• Molecular weight: 213.19

Troxacitabine

CAS: 145918-75-8

Troxacitabine is a nucleoside analog that inhibits DNA synthesis by selectively blocking the function of …

• Formula: C₈H₁₁N₃O₄
• Purity: Min. 95%
• Color and Shape: White To Off-White Solid
• Molecular weight: 213.19 g/mol