CAS 145986-07-8

1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4(1H,3H)-dione

Description:

1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4(1H,3H)-dione, with CAS number 145986-07-8, is a chemical compound characterized by its unique structural features that include a pyrimidine ring and an oxathiolane moiety. The presence of the hydroxymethyl group contributes to its potential reactivity and solubility in polar solvents. This compound is of interest in medicinal chemistry, particularly for its potential biological activities, which may include antiviral or antitumor properties. The stereochemistry indicated by the (2R,5S) configuration suggests specific spatial arrangements that can influence the compound's interactions with biological targets. Additionally, the dione functional groups imply the presence of two carbonyl functionalities, which can participate in various chemical reactions, including nucleophilic attacks and hydrogen bonding. Overall, this compound's structural complexity and functional groups make it a subject of interest for further research in drug development and synthetic chemistry.

Formula: C₈H₁₀N₂O₄S

InChI: InChI=1/C8H10N2O4S/c11-3-7-14-6(4-15-7)10-2-1-5(12)9-8(10)13/h1-2,6-7,11H,3-4H2,(H,9,12,13)/t6-,7+/m0/s1

Zidovudine and lamivudine impurity standard

CAS: 145986-07-8

Zidovudine and lamivudine impurity standard

Color and Shape: White

Ref: 47-850

Lamivudine Uracil Derivative (1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4(1H,3H)-dione)

CAS: 145986-07-8

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₈H₁₀N₂O₄S

Color and Shape: White Off-White Powder

Molecular weight: 230.03613

Ref: 45-1A05130

Lamivudine EP Impurity J

CAS: 145986-07-8

Formula: C₈H₁₀N₂O₄S

Color and Shape: White To Off-White Solid

Molecular weight: 230.24

Ref: 4Z-L-2012

1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidine-2,4(1H,3H)-dione

CAS: 145986-07-8

Color and Shape: Neat

Ref: 86-MM0749.10

Lamivudine EP Impurity J

CAS: 145986-07-8

Formula: C₈H₁₀N₂O₄S

Molecular weight: 230.24

Ref: ST-EA-CP-L3010

(2R-cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione

Controlled Product

CAS: 145986-07-8

Impurity Lamivudine EP Impurity J
Applications (2R-cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione (Lamivudine EP Impurity J) is an impurity of Lamivudine (L172500). (2R-cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione is also being further studied to determine its potential as an anti-HIV agent.
References Jeong, L., et al.: J. Med. Chem., 36, 181 (1993)

Formula: C₈H₁₀N₂O₄S

Color and Shape: White

Molecular weight: 230.24

Ref: TR-L172535

(2R-cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione-13C, 15N2

Controlled Product

CAS: 145986-07-8

Formula: CC₇H₁₀₁₅N₂O₄S

Color and Shape: Neat

Molecular weight: 233.22

Ref: TR-L172537

(2R-Cis)-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione

CAS: 145986-07-8

(2R-Cis)-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione is a cytosine analog. It has been synthesized by the reaction of 2,4,6-trichlorobenzoyl chloride and 3-amino-5-(hydroxymethyl)oxolane in liquid chromatography. The product contains impurities of lamivudine and uracil.

Formula: C₈H₁₀N₂O₄S

Purity: Min. 95%

Molecular weight: 230.24 g/mol

Ref: 3D-VFA98607