CAS 146-48-5

yohimbine

Description:

Yohimbine is an indole alkaloid derived from the bark of the Yohimbe tree (Pausinystalia yohimbe), primarily found in Central and West Africa. It is known for its pharmacological properties, particularly as an alpha-2 adrenergic antagonist, which can lead to increased sympathetic nervous system activity. This characteristic makes yohimbine notable in the context of its use as a dietary supplement for weight loss and as an aphrodisiac. The compound is typically encountered as a white to off-white crystalline powder and is soluble in organic solvents like ethanol and methanol, but has limited solubility in water. Yohimbine's mechanism of action involves blocking alpha-2 adrenergic receptors, which can enhance norepinephrine release and promote vasodilation. It is important to note that yohimbine can have side effects, including increased heart rate, anxiety, and gastrointestinal disturbances, and should be used with caution, particularly in individuals with pre-existing health conditions. As with any supplement, consulting a healthcare professional before use is advisable.

Formula: C₂₁H₂₆N₂O₃

InChI: InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1

InChI key: InChIKey=BLGXFZZNTVWLAY-SCYLSFHTSA-N

SMILES: C(OC)(=O)[C@@H]1[C@]2(C[C@]3(C4=C(C=5C(N4)=CC=CC5)CCN3C[C@@]2(CC[C@@H]1O)[H])[H])[H]

Synonyms:

• 17Alpha-Hydroxy-Yohimban-16Alpha-Carboxylic Acid Methyl Ester
• Aphrodine
• Aphrosol
• Benz[g]indolo[2,3-a]quinolizine, yohimban-16-carboxylic acid deriv.
• Corynine
• Methyl (16Alpha,17Alpha)-17-Hydroxyyohimban-16-Carboxylate
• Methyl (16Alpha,17Alpha)-17-Hydroxyyohimban-16-Carboxylate Hydrochloride (1:1)
• Quebrachin
• Quebrachine
• Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16α,17α)-
• Yohimban-16α-carboxylic acid, 17α-hydroxy-, methyl ester
• Yohimbic acid methyl ester
• Yohimbin
• Yohimbina
• Yohimbol-16α-carboxylic acid, methyl ester

Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16α,17α)-

CAS: 146-48-5

Formula: C₂₁H₂₆N₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 354.4427

Ref: IN-DA001DLL

Yohimbine

CAS: 146-48-5

Yohimbine

Purity: ≥98%

Molecular weight: 354.4g/mol

Ref: 54-BUP15987

Yohimbine

CAS: 146-48-5

Yohimbine is a nonselective alpha 2-adrenergic receptor (AR) antagonist(IC50 : 0.6 μM)

Formula: C₂₁H₂₆N₂O₃

Purity: 99.78% - 99.89%

Color and Shape: Solid

Molecular weight: 354.4

Ref: TM-TCS2185

Yohimbine

CAS: 146-48-5

Formula: C₂₁H₂₆N₂O₃

Purity: 95%~99%

Molecular weight: 354.45

Ref: BP-BP1461

Yohimbe bark

CAS: 146-48-5

Yohimbe bark is a phytotherapeutic agent, derived from the bark of the Pausinystalia johimbe tree, which is an evergreen species native to Central and West Africa. This product acts primarily through its active compound called yohimbine, which functions as an alpha-2 adrenergic receptor antagonist. By blocking these receptors, yohimbine increases the release of norepinephrine, leading to enhanced sympathetic nervous system activity. This pharmacological action results in vasodilation, promoting increased blood flow, particularly to peripheral tissues.

Formula: C₂₁H₂₆N₂O₃

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 354.44 g/mol

Ref: 3D-FY01219

17α-Hydroxy-yohimban-16α-carboxylic Acid Methyl Ester

Controlled Product

CAS: 146-48-5

Applications 17alpha-Hydroxy-yohimban-16alpha-carboxylic acid methyl ester (cas# 146-48-5) is a useful research chemical.Also, it is an intermediate used in the synthesis of Corynanthine (C696915), which is a alkaloids from root samples of R. serpentina and it possesses cytotoxic activities against human breast cancer cells.
References Sagi, S., et al.: Anal. Bioanal. Chem., 408, 177-190 (2016); Cohen, P. A., et al.: Drug Test. Anal., 8, 357-369 (2016); Wang, C., et al.: Chem. Nat. Compd., 49, 1177-1178 (2014)

Formula: C₂₁H₂₆N₂O₃

Color and Shape: Neat

Molecular weight: 352.54

Ref: TR-H998228