CAS 146-78-1

2-Fluoroadenosine

Description:

2-Fluoroadenosine is a modified nucleoside that features a fluorine atom substituted at the 2-position of the adenine base. Its molecular formula is C10H12FN5O3, and it is classified as a purine nucleoside, which is a building block of nucleic acids. This compound is known for its potential applications in biochemistry and pharmacology, particularly in the study of nucleoside analogs and their effects on cellular processes. The presence of the fluorine atom can influence the compound's biological activity, stability, and interaction with enzymes and receptors. 2-Fluoroadenosine is often used in research to explore mechanisms of action in cellular signaling pathways and to investigate its potential as an antiviral or anticancer agent. Its solubility and reactivity can vary depending on the conditions, making it a subject of interest in medicinal chemistry. As with many nucleoside analogs, understanding its pharmacokinetics and biological effects is crucial for developing therapeutic applications.

Formula: C₁₀H₁₂FN₅O₄

InChI: InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1

InChI key: InChIKey=HBUBKKRHXORPQB-UUOKFMHZSA-N

SMILES: NC1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)=NC(F)=N1

Synonyms:

• 2-Fluoro-9-β-<span class="text-smallcaps">D</span>-ribofuranosyladenine
• 2-Fluoroadenosine
• 2-fluoro-9-pentofuranosyl-9H-purin-6-amine
• Adenosine, 2-fluoro-
• NSC 30605
• 2-Fluoro-9-β-D-ribofuranosyladenine

2-Fluoroadenosine

CAS: 146-78-1

Formula: C₁₀H₁₂FN₅O₄

Purity: >96.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 285.24

Ref: 3B-F0656

Adenosine, 2-fluoro-

CAS: 146-78-1

Formula: C₁₀H₁₂FN₅O₄

Purity: 96%

Color and Shape: Solid

Molecular weight: 285.2318

Ref: IN-DA001DM5

2-Fluoroadenosine

CAS: 146-78-1

2-Fluoroadenosine

Purity: ≥98%

Molecular weight: 285.23g/mol

Ref: 54-BUP17612

2-Fluoroadenosine

CAS: 146-78-1

2-Fluoroadenosine

Purity: 98%

Molecular weight: 285.23g/mol

Ref: 54-BI1015

2''-Fluoroadenosine

CAS: 146-78-1

Formula: C₁₀H₁₂FN₅O₄

Molecular weight: 285.23

Ref: 7W-GE9890

2-Fluoroadenosine, 10mM (in DMSO)

CAS: 146-78-1

2-Fluoroadenosine, 10mM (in DMSO)

Purity: ≥95%

Molecular weight: 285.23g/mol

Ref: 54-BUP19993

2-Fluoroadenosine

CAS: 146-78-1

2-Fluoroadenosine is a potent inhibitor of lymphocyte-mediated cytolysis.

Formula: C₁₀H₁₂FN₅O₄

Purity: 98% - 99.67%

Color and Shape: White To Yellowish Crystalline Powder

Molecular weight: 285.23

Ref: TM-T7981

2-Fluoroadenosine

Controlled Product

CAS: 146-78-1

Applications 2-Fluoroadenosine is a fluorinated analog of Adenoside (A280400) nucleotide.
References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010);

Formula: C₁₀H₁₂FN₅O₄

Color and Shape: Neat

Molecular weight: 285.23

Ref: TR-F587218

(2R,3R,4S,5R)-2-(6-Amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

CAS: 146-78-1

Formula: C₁₀H₁₂FN₅O₄

Purity: 96%

Color and Shape: Solid, White to almost white powder

Molecular weight: 285.235

Ref: 10-F093368

2-Fluoroadenosine

CAS: 146-78-1

2-Fluoroadenosine is a nucleoside that has shown high resistance to the enzyme cyclase. This property may be due to its structural and conformational properties, which are different from those of adenosine. 2-Fluoroadenosine has been shown to inhibit the synthesis of ATP in ventricular myocardium and fat cells, as well as increase levels of adenylate kinase in blood. It has also been shown to have potential as a drug target for autoimmune diseases, such as multiple sclerosis. 2-Fluoroadenosine can be used for biochemical and pharmacokinetic studies because it is rapidly metabolized by the liver and excreted in urine.
2-Fluoroadenosine can also be used to measure changes in the ratio of adenylate kinase:adenylate kinase reductase (AKAR) in blood plasma.

Formula: C₁₀H₁₂FN₅O₄

Purity: Min. 95%

Color and Shape: White Slightly Yellow Powder

Molecular weight: 285.23 g/mol

Ref: 3D-NF08852