CAS 146062-46-6

2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-, hydrochloride (1:1)

Description:

2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-, hydrochloride (1:1), commonly referred to as a thiazolidinedione derivative, is a synthetic compound primarily studied for its potential therapeutic applications, particularly in the management of diabetes. This compound features a thiazolidinedione core, which is known for its role in enhancing insulin sensitivity. The presence of a pyridine ring and an ethoxy group contributes to its structural complexity and may influence its pharmacological properties. As a hydrochloride salt, it is typically more soluble in water, facilitating its use in biological studies. The compound's mechanism of action may involve modulation of peroxisome proliferator-activated receptors (PPARs), which are crucial in lipid and glucose metabolism. Its safety profile, efficacy, and specific interactions with biological systems are subjects of ongoing research, making it a compound of interest in medicinal chemistry and pharmacology. As with any pharmaceutical agent, understanding its characteristics, including solubility, stability, and biological activity, is essential for its development and application.

Formula: C₁₉H₂₀N₂O₄S·ClH

InChI: InChI=1S/C19H20N2O4S.ClH/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17;/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24);1H

InChI key: InChIKey=SBHOQYCDAHAMDW-UHFFFAOYSA-N

SMILES: C(C1C(=O)NC(=O)S1)C2=CC=C(OCCC3=CC=C(C(C)O)C=N3)C=C2.Cl

Synonyms:

• Leriglitazone hydrochloride
• MIN 102
• all-ambo-5-[(4-{2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy}phenyl)methyl]-1,3-thiazole-2,4(3H,5H)-dione hydrocloride (1:1)
• 2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-, monohydrochloride
• 2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-, hydrochloride (1:1)

Leriglitazone hydrochloride

CAS: 146062-46-6

Leriglitazone hydrochloride, a pioglitazone metabolite, is a PPARγ agonist with Ki of 1.2 μM and EC50 of 680 nM.

Formula: C₁₉H₂₁ClN₂O₄S

Color and Shape: Solid

Molecular weight: 408.90

Ref: TM-T73842

1-Hydroxy Pioglitazone Hydrochloride

Controlled Product

CAS: 146062-46-6

Formula: C₁₉H₂₀N₂O₄S·ClH

Color and Shape: Neat

Molecular weight: 408.899

Ref: TR-H952090

1-Hydroxy pioglitazone hydrochloride

CAS: 146062-46-6

Pioglitazone is a thiazolidinedione antidiabetic agent that is used to treat type 2 diabetes. Pioglitazone has been shown to have the potential to attenuate insulin resistance and decrease hepatic glucose output. Pioglitazone has also been shown to inhibit many of the enzymes involved in the metabolism of glucose, such as glucokinase, phosphoenolpyruvate carboxykinase, and pyruvate dehydrogenase. In addition, pioglitazone has been shown to increase insulin sensitivity by increasing the number of insulin receptors on cell membranes. Pioglitazone has also been shown to reduce blood pressure through its effects on erythropoietin activity and nitric oxide production. This drug may act as an antioxidant by inhibiting peroxidation of lipids in the liver. Pioglitazone has also been studied for its effect on nervous system diseases, such as Alzheimer's disease and X

Formula: C₁₉H₂₁ClN₂O₄S

Purity: Min. 95%

Molecular weight: 408.9 g/mol

Ref: 3D-WFA06246