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CAS 14611-51-9

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Selegiline

Description:
Selegiline, also known as L-deprenyl, is a selective monoamine oxidase B (MAO-B) inhibitor primarily used in the treatment of Parkinson's disease and major depressive disorder. It is characterized by its ability to increase levels of dopamine in the brain by inhibiting its breakdown, thereby enhancing dopaminergic activity. Selegiline is typically administered in its hydrochloride salt form and is available in various formulations, including tablets and transdermal patches. The substance is known for its neuroprotective properties and may also exhibit some antidepressant effects. Chemically, selegiline is a phenethylamine derivative, and its structure includes a propargyl group, which contributes to its unique mechanism of action. It is generally well-tolerated, but potential side effects can include insomnia, dizziness, and gastrointestinal disturbances. Due to its MAO-B inhibition, caution is advised when used in conjunction with certain medications and dietary tyramine, as it can lead to hypertensive crises. Overall, selegiline represents a significant therapeutic option in managing specific neurological and psychiatric conditions.
Formula:C13H17N
InChI:InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1
InChI key:InChIKey=MEZLKOACVSPNER-GFCCVEGCSA-N
SMILES:C([C@H](N(CC#C)C)C)C1=CC=CC=C1
Synonyms:
  • Phenethylamine, N,α-dimethyl-N-2-propynyl-, L-(-)-
  • Benzeneethanamine, N,α-dimethyl-N-2-propyn-1-yl-, (αR)-
  • Benzeneethanamine, N,α-dimethyl-N-2-propynyl-, (R)-
  • (αR)-N,α-Dimethyl-N-2-propyn-1-ylbenzeneethanamine
  • Benzeneethanamine, N,α-dimethyl-N-2-propynyl-, (αR)-
  • Emsam
  • Selegilinum [INN-Latin]
  • Anipryl
  • Selegilinum
  • Jumex
  • See more synonyms
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