CAS 146255-66-5

(RS)-3,5-DHPG

Description:

(RS)-3,5-DHPG, or (RS)-3,5-Dihydroxyphenylglycine, is a chemical compound that functions primarily as a selective agonist for metabotropic glutamate receptors, particularly mGluR2 and mGluR3. This compound is notable for its role in neuroscience research, as it is often used to study synaptic transmission and plasticity in the central nervous system. Structurally, it features a phenyl ring with two hydroxyl groups and a glycine moiety, contributing to its biological activity. The compound is typically characterized by its ability to modulate neurotransmitter release and influence various neurological processes, making it a valuable tool in pharmacological studies. Additionally, (RS)-3,5-DHPG is often investigated for its potential therapeutic applications in conditions such as anxiety, depression, and other neuropsychiatric disorders. Its solubility and stability in various solvents are also important for its application in laboratory settings. Overall, (RS)-3,5-DHPG serves as a significant compound in the exploration of glutamatergic signaling pathways.

Formula: C₈H₉NO₄

InChI: InChI=1/C8H9NO4/c10-6-1-5(2-7(11)3-6)9-4-8(12)13/h1-3,9-11H,4H2,(H,12,13)

InChI key: InChIKey=HOOWCUZPEFNHDT-UHFFFAOYSA-N

SMILES: C(C(O)=O)(N)C1=CC(O)=CC(O)=C1

Synonyms:

• (2S)-amino(3,5-dihydroxyphenyl)ethanoic acid
• (<span class="text-smallcaps">D</smallcap>/<smallcap>L</span>)-3,5-Dihydroxyphenylglycine
• (Rs)-3,5-Dihydroxyphenylglycine
• (±)-α-Amino-3,5-dihydroxybenzeneacetic acid
• 2-Amino-2-(3,5-dihydroxyphenyl)acetic acid
• 3,5-Dihydroxyphenylglycine
• <span class="text-smallcaps">D</smallcap><smallcap>L</span>-2-(3,5-Dihydroxyphenyl)glycine
• Amino(3,5-Dihydroxyphenyl)Acetic Acid
• Benzeneacetic acid, α-amino-3,5-dihydroxy-
• Dl-Alpha-(3,5-Dihydroxyphenyl)Glycine
• N-(3,5-dihydroxyphenyl)glycine
• DL-2-(3,5-Dihydroxyphenyl)glycine
• a-Amino-3,5-dihydroxy-benzeneacetic acid HCl

DHPG

CAS: 146255-66-5

DHPG is a potent Group I mGluR agonist; doesn't affect Group II/III; linked to phospholipase D.

Formula: C₈H₉NO₄

Purity: 99.55%

Color and Shape: Solid

Molecular weight: 183.16

Ref: TM-T11032

(RS)-3,5-Dhpg

CAS: 146255-66-5

Formula: C₈H₉NO₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 183.1614

Ref: IN-DA00AL0D

DHPG

CAS: 146255-66-5

DHPG

Purity: ≥98%

Molecular weight: 183.16g/mol

Ref: 54-BUP06670

2-AMINO-2-(3,5-DIHYDROXYPHENYL)ACETIC ACID

CAS: 146255-66-5

Purity: 95%

Molecular weight: 183.1629944

Ref: 10-F856866

(RS)-3,5-DHPG

Controlled Product

CAS: 146255-66-5

Applications (RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGluR1 and mGluR5. It has been shown that (RS)-3,5-DHPG can modulate Kir4.1 protein and mRNA in cultured rat retinal Müller cells.(RS)-3,5-DHPG acts as a potential target in treatment of parkinson's disease.
References (1) Gao, F., et al.: Neurosci Lett. 588, 12 (2015)

Formula: C₈H₉NO₄

Color and Shape: Neat

Molecular weight: 183.16

Ref: TR-D450028

(RS)-3,5-DHPG

CAS: 146255-66-5

(RS)-3,5-DHPG is a cytosolic protein that has been shown to have a physiological effect on neuronal function. It enhances neuronal function by binding to the ryanodine receptor and activating it. This activation of the ryanodine receptor leads to an increase in calcium levels in the cytosol and an increase in camp levels. The binding of (RS)-3,5-DHPG to the ryanodine receptor also increases glutamate release, which may contribute to its effects on neuronal function. (RS)-3,5-DHPG is not active at the cell membrane level.

Formula: C₈H₉NO₄

Purity: Min. 95%

Molecular weight: 183.16 g/mol

Ref: 3D-WFA25566