CAS 146269-94-5

AF2 neuropeptide

Description:

AF2 neuropeptide, identified by its CAS number 146269-94-5, is a synthetic peptide that plays a role in neurobiology, particularly in the modulation of neuronal activity and signaling pathways. This neuropeptide is characterized by its specific amino acid sequence, which influences its biological activity and interaction with receptors in the nervous system. AF2 neuropeptide is known to exhibit properties such as neuroprotective effects, modulation of pain perception, and potential roles in stress response and mood regulation. Its structure typically includes a sequence of amino acids that can form specific secondary structures, contributing to its stability and function. The peptide's activity is often studied in the context of neurodegenerative diseases and psychiatric disorders, making it a subject of interest in pharmacological research. Additionally, AF2 neuropeptide may interact with various neurotransmitter systems, highlighting its potential therapeutic applications in neurology and psychiatry.

Formula: C₄₇H₇₀N₁₄O₁₀

InChI: InChI=1/C47H70N14O10/c1-27(2)21-36(44(69)56-33(12-8-20-54-47(51)52)42(67)58-35(40(50)65)22-28-9-4-3-5-10-28)60-45(70)37(23-29-13-15-31(62)16-14-29)61-43(68)34(17-18-39(63)64)57-46(71)38(24-30-25-53-26-55-30)59-41(66)32(49)11-6-7-19-48/h3-5,9-10,13-16,25-27,30,32-38,62H,6-8,11-12,17-24,48-49H2,1-2H3,(H2,50,65)(H,56,69)(H,57,71)(H,58,67)(H,59,66)(H,60,70)(H,61,68)(H,63,64)(H4,51,52,54)/t30?,32-,33-,34-,35-,36-,37-,38-/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](Cc1ccccc1)C(=N)O)O)O)N=C([C@H](Cc1ccc(cc1)O)N=C([C@H](CCC(=O)O)N=C([C@H](CC1C=NC=N1)N=C([C@H](CCCCN)N)O)O)O)O

Synonyms:

• Fmrfamidelike peptide AF2
• Lys-his-glu-tyr-leu-arg-phe-NH2
• L-Phenylalaninamide, L-lysyl-L-histidyl-L-alpha-glutamyl-L-tyrosyl-L-leucyl-L-arginyl-
• L-lysyl-3-(4H-imidazol-4-yl)-L-alanyl-L-alpha-glutamyl-L-tyrosyl-L-leucyl-N~5~-(diaminomethylidene)-L-ornithyl-L-phenylalaninamide
• AF2 Neuropeptide
• AF-2 H-Lys-His-Glu-Tyr-Leu-Arg-Phe-NH2
• L-Phenylalaninamide, L-lysyl-L-histidyl-L-α-glutamyl-L-tyrosyl-L-leucyl-L-arginyl-
• (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino

L-Phenylalaninamide, L-lysyl-L-histidyl-L-α-glutamyl-L-tyrosyl-L-leucyl-L-arginyl-

CAS: 146269-94-5

Formula: C₄₇H₇₀N₁₄O₁₀

Molecular weight: 991.1465

Ref: IN-DA001DU0

AF2 Neuropeptide

CAS: 146269-94-5

AF2 is the nematode neuropeptide. It also increases voltage-activated calcium currents in Ascaris suum muscle.

Formula: C₄₇H₇₀N₁₄O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 991.15

Ref: TM-TP2329

(4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino ]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino

CAS: 146269-94-5

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₄₇H₇₀N₁₄O₁₀

Molecular weight: 991.17 g/mol

Ref: 3D-PP50018

AF-2

CAS: 146269-94-5

AF-2 is a potent, selective and competitive antagonist at the nicotinic acetylcholine receptor (nAChR). AF-2 binds to the extracellular domains of the nAChR and prevents agonists from binding. It has been shown to inhibit acetylcholine release in isolated heart preparations with high affinity and selectivity. The drug has been tested as an anthelmintic against Caenorhabditis elegans and found to be effective. AF-2 is a cholinergic compound that binds to ganglia, leading to a biphasic response. It also has significant effects on the central nervous system, inhibiting both nicotinic and muscarinic acetylcholine receptors.
AF-2 is sequenced according to the following formula:
H-Lys-His-Glu-Tyr-Leu-Arg-Phe
NH2

Formula: C₄₇H₇₀N₁₄O₁₀

Purity: Min. 95%

Molecular weight: 991.15 g/mol

Ref: 3D-FA108494