CAS 146275-15-2

COTININE-N-(4-DEOXY-4,5-DIDEHYDRO)-?-D-GLUCURONIDE

Description:

Cotinine-N-(4-deoxy-4,5-didehydro)-β-D-glucuronide is a metabolite of cotinine, which is a primary metabolite of nicotine. This compound is characterized by its glucuronidation, a biochemical process where a glucuronic acid moiety is conjugated to a substrate, enhancing its solubility and facilitating excretion. The presence of the 4-deoxy-4,5-didehydro modification indicates structural alterations that may influence its biological activity and pharmacokinetics. Cotinine itself is known for its relatively long half-life compared to nicotine, and its glucuronide forms are often used as biomarkers for tobacco exposure in biological samples. The compound is typically analyzed using techniques such as liquid chromatography coupled with mass spectrometry (LC-MS) due to its complex structure and the need for sensitivity in detection. Understanding the characteristics of this glucuronide can provide insights into nicotine metabolism and the physiological effects of tobacco use.

Formula: C₁₆H₁₈N₂O₆

InChI: InChI=1/C16H18N2O6/c1-17-10(4-5-13(17)20)9-3-2-6-18(8-9)15-14(21)11(19)7-12(24-15)16(22)23/h2-3,6-8,10-11,14-15,19,21H,4-5H2,1H3/t10-,11+,14+,15-/m0/s1

Synonyms:

• N-(-D-4-Deoxy-4,5-didehydroglucopyranosyl)uronate, Cotinium Inner Salt
• COTININE-N-(4-DEOXY-4,5-DIDEHYDRO)-?-D-GLUCURONIDE

Cotinine N-(4-Deoxy-4,5-didehydro)-b-D-glucuronide

CAS: 146275-15-2

Formula: C₁₆H₁₈N₂O₆

Color and Shape: Solid

Molecular weight: 334.3239

Ref: IN-DA001DTW

Cotinine N-(4-deoxy-4,5-didehydro)-b-D-glucuronide

CAS: 146275-15-2

Ref: 7W-GC6235

Cotinine N-(4-Deoxy-4,5-didehydro)-Beta-D-glucuronide

CAS: 146275-15-2

Formula: C₁₆H₁₈N₂O₆

Ref: TR-TRC-C725160

Cotinine N-(4-Deoxy-4,5-didehydro)-β-D-glucuronide

Controlled Product

CAS: 146275-15-2

Stability Hygroscopic
Applications A major metabolite of Nicotine in humans. Carcinogen.
References Benowitz, N., et al.: Clin. Pharmacol. Ther., 56, 483 (1994), Nakajima, M., et al.: Drug Metab. Dispos., 24, 1212 (1996), Messina, E., et al.: J. Pharmacol. Exp. Ther., 282, 1608 (1997), Oscarson, M., et al.: Hum. Mutat., 20, 275 (2002),

Formula: C₁₆H₁₈N₂O₆

Color and Shape: Neat

Molecular weight: 334.32

Ref: TR-C725160

Cotinine N-(4-deoxy-4,5-didehydro)-b-D-glucuronide

CAS: 146275-15-2

Cotinine N-(4-deoxy-4,5-didehydro)-b-D-glucuronide is a custom synthesis and modification of cotinine. Cotinine is an alkaloid found in tobacco plants and the primary metabolite of nicotine. It has been shown to inhibit glycosylation, methylation, and carbohydrate modification reactions. This product is offered in high purity and with a CAS number of 146275-15-2.

Formula: C₁₆H₁₈N₂O₆

Purity: Min. 95%

Molecular weight: 334.32 g/mol

Ref: 3D-MC16664