CAS 146275-18-5

trans-3'-Hydroxycotinine-N-b-D-glucuronide

Description:

Trans-3'-Hydroxycotinine-N-b-D-glucuronide is a metabolite of nicotine, specifically a glucuronide conjugate of 3'-hydroxycotinine, which is a primary metabolite of nicotine in the human body. This compound is characterized by its glucuronidation, a biochemical process that involves the addition of glucuronic acid to a substrate, enhancing its solubility and facilitating excretion. The structure of trans-3'-Hydroxycotinine-N-b-D-glucuronide includes a hydroxyl group and a glucuronide moiety, which contribute to its polar nature. This polar characteristic is significant for its pharmacokinetics, as it influences the compound's absorption, distribution, metabolism, and excretion. The compound is primarily studied in the context of nicotine metabolism and its implications for tobacco use and dependence. Its presence in biological samples can serve as a biomarker for nicotine exposure. Overall, trans-3'-Hydroxycotinine-N-b-D-glucuronide plays a crucial role in understanding the metabolic pathways of nicotine and its effects on human health.

Formula: C₁₆H₂₀N₂O₈

InChI: InChI=1/C16H20N2O8/c1-18-8(7-3-2-4-17-6-7)5-9(14(18)22)25-16-12(21)10(19)11(20)13(26-16)15(23)24/h2-4,6,8-13,16,19-21H,5H2,1H3,(H,23,24)

SMILES: CN1C(CC(C1=O)OC1C(C(C(C(C(=O)O)O1)O)O)O)c1cccnc1

Synonyms:

• trans-3-Hydroxycotinine glucuronide
• 1-Methyl-2-Oxo-5-(Pyridin-3-Yl)Pyrrolidin-3-Yl Hexopyranosiduronic Acid

N-(trans-3-Hydroxycotinine)-b-D-glucuronide

CAS: 146275-18-5

Ref: 7W-GC7509

trans-3'-Hydroxy Cotinine N-β-D-Glucuronide

CAS: 146275-18-5

Formula: C₁₆H₂₀N₂O₈

Molecular weight: 368.34

Ref: 4Z-C-5527

trans-3'-Hydroxy Cotinine N-β-D-Glucuronide

Controlled Product

CAS: 146275-18-5

Applications It is a major metabolite of Nicotine in humans. Carcinogen.
References Byrd, G., et al.: Drug Metab. Dispos., 20, 192 (1992), Benowitz, N., et al.: Br. J. Clin. Pharmacol., 51, 53 (2001), Hanioka, N., et al.: Xenobiotica, 31, 687 (2001), Ethell, B., et al.: Biochem. Pharmacol., 65, 1441 (2003), Yamanaka, H., et al.: Eur. J. Pharm. Sci., 22, 419 (2004),

Formula: C₁₆H₂₀N₂O₈

Color and Shape: Neat

Molecular weight: 368.34

Ref: TR-H924530

trans-3'-Hydroxy Cotinine-d3 N-β-D-Glucuronide

Controlled Product

CAS: 146275-18-5

Applications A Nicotine metabolite. Carcinogen.

Formula: C₁₆H₁₇D₃N₂O₈

Color and Shape: Neat

Molecular weight: 371.36

Ref: TR-H924535

N-(trans-3-Hydroxycotinine)-b-D-glucuronide

CAS: 146275-18-5

N-(trans-3-Hydroxycotinine)-b-D-glucuronide is a hydroxy metabolite of trans-3-hydroxycotinine, which is a pyridine derivative and an endogenous metabolite of nicotine. It is formed by conjugation with glucuronate in the liver and excreted in the urine. It has been detected in human urine after oral administration of nicotine. N-(trans-3-Hydroxycotinine)-b-D-glucuronide can be used as an indicator for tobacco exposure or use.

Formula: C₁₆H₂₀N₂O₈

Purity: Min. 95%

Molecular weight: 368.34 g/mol

Ref: 3D-MH07435