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CAS 146340-20-7

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Activated Protein C (390-404) (human)

Description:
Activated Protein C (APC) is a serine protease that plays a crucial role in the regulation of blood coagulation and inflammation. It is derived from Protein C, which is activated by the thrombin-thrombomodulin complex. The specific fragment "390-404" refers to a portion of the human APC protein, indicating its amino acid sequence and structural characteristics. APC functions primarily by inactivating Factors Va and VIIIa, thereby downregulating the coagulation cascade and promoting anticoagulation. This mechanism is vital for maintaining hemostatic balance and preventing excessive clot formation. Additionally, APC has anti-inflammatory properties, influencing various cellular processes, including apoptosis and endothelial cell function. The CAS number 146340-20-7 uniquely identifies this specific form of Activated Protein C, facilitating its recognition in scientific literature and regulatory contexts. Overall, APC is significant in both physiological and pathological processes, including its therapeutic potential in conditions such as sepsis and thrombosis.
Formula:CH130N22O23
Synonyms:
  • H-Tyr-Gly-Val-Tyr-Thr-Lys-Val-Ser-Arg-Tyr-Leu-Asp-Trp-Ile-His-OH
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