CAS 146346-82-9

FMOC-THR(TBDMS)-OH

Description:

FMOC-THR(TBDMS)-OH, also known as 2-amino-3-(9-fluorenylmethoxycarbonyl)-4-(tert-butyldimethylsilyl)butanoic acid, is a protected form of the amino acid threonine. This compound features a fluorenylmethoxycarbonyl (FMOC) group, which serves as a protective group for the amino functionality, allowing for selective reactions in peptide synthesis. The tert-butyldimethylsilyl (TBDMS) group protects the hydroxyl group of threonine, enhancing its stability during synthetic procedures. FMOC-THR(TBDMS)-OH is typically used in solid-phase peptide synthesis, where the protection of functional groups is crucial for the successful assembly of peptides. The compound is generally stable under standard laboratory conditions but may require specific conditions for deprotection. Its solubility is influenced by the presence of the bulky FMOC and TBDMS groups, often making it soluble in organic solvents while being less soluble in water. Overall, FMOC-THR(TBDMS)-OH is an important intermediate in the synthesis of peptides and proteins, facilitating the incorporation of threonine into larger molecular structures.

Formula: C₂₅H₃₃NO₅Si

Synonyms:

• Fmoc-L-Thr(Tbdms)-Oh
• N-Alpha-(9-Fluorenylmethyloxycarbonyl)-O-(Tert-Butyl-Dimethylsilyl)-L-Threonine
• Fmoc-O-(Tert.-Butyldimethylsilyl)-L-Threonine
• N-Alpha-(9-Fluorenylmethyloxycarbonyl)-O-(T-Butyl-Dimethylsilyl)-L-Threonine
• N-Alpha-(9-Fluoroenylmethyloxycarbonyl)-O-(T-Butyl-Dimethylsilyl)-L-Threonine

L-Threonine, O-[(1,1-dimethylethyl)dimethylsilyl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

CAS: 146346-82-9

Formula: C₂₅H₃₃NO₅Si

Purity: 98%

Color and Shape: Solid

Molecular weight: 455.6187

Ref: IN-DA001DXM

Fmoc-Thr(TBDMS)-OH

CAS: 146346-82-9

Fmoc-Thr(TBDMS)-OH

Purity: 97%

Molecular weight: 455.63g/mol

Ref: 54-OR1055835

Fmoc-Thr(TBDMS)-OH

CAS: 146346-82-9

Formula: C₂₅H₃₃NO₅Si

Purity: ≥ 97.0%

Color and Shape: White to off-white powder

Molecular weight: 455.62

Ref: 7W-GM5290

Fmoc-Thr(TBDMS)-OH

CAS: 146346-82-9

Fmoc-Thr(TBDMS)-OH is an ether-based protecting group. The etherate group is a good nucleophile, which can be cleaved by fluoride. This group is also selective, so it can be used in peptide synthesis. Fmoc-Thr(TBDMS)-OH selectively undergoes cleavage at the N-terminal amino acid residue by treatment with fluoride. It is an ether that has a high affinity for magnesium. It has an aliphatic side chain and carbamate or ester groups that are not reactive to fluorine. Fmoc-Thr(TBDMS)-OH is a methodology for organic chemistry, which uses fluoride to cleave the etherate group from the N-terminal amino acid residue of a peptide.

Formula: C₂₅H₃₃NO₅Si

Purity: Min. 95%

Molecular weight: 455.62 g/mol

Ref: 3D-WFA34682