CAS 146362-70-1

Meclinertant

Description:

Meclinertant, with the CAS number 146362-70-1, is a chemical compound that functions primarily as an antagonist of the neurokinin-1 (NK1) receptor. This receptor is involved in various physiological processes, including pain perception, stress response, and the regulation of mood. Meclinertant has been studied for its potential therapeutic applications, particularly in the treatment of conditions such as anxiety and depression, as well as in managing nausea and vomiting associated with chemotherapy. The compound exhibits a specific binding affinity for the NK1 receptor, which helps modulate the effects of substance P, a neuropeptide associated with pain and inflammation. In terms of its physical and chemical properties, Meclinertant is typically characterized by its molecular structure, which includes specific functional groups that contribute to its biological activity. As with many pharmacological agents, understanding its pharmacokinetics, metabolism, and potential side effects is crucial for evaluating its efficacy and safety in clinical settings.

Formula: C₃₂H₃₁ClN₄O₅

InChI: InChI=1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40)

InChI key: InChIKey=DYLJVOXRWLXDIG-UHFFFAOYSA-N

SMILES: N(C(=O)C1=NN(C(=C1)C2=C(OC)C=CC=C2OC)C=3C4=C(N=CC3)C=C(Cl)C=C4)C5(C(O)=O)C6CC7CC5CC(C6)C7

Synonyms:

• 2-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.1~3,7~]decane-2-carboxylic acid
• 2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]tricyclo[3.3.1.1^3,7]decane-2-carboxylic acid
• Meclinertant
• Reminertant
• Sr-48692
• Tricyclo[3.3.1.1^3,7]decane-2-carboxylic acid, 2-[[[1-(7-chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-
• Tricyclo[3.3.1.13,7]decane-2-carboxylic acid, 2-[[[1-(7-chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-
• 2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]tricyclo[3.3.1.13,7]decane-2-carboxylic acid

2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]tricyclo[3.3.1.13,7]decane-2-carboxylic acid

CAS: 146362-70-1

Formula: C₃₂H₃₁ClN₄O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 587.0653

Ref: IN-DA001DYD

Meclinertant

CAS: 146362-70-1

Meclinertant: selective NTS1 antagonist, blocks Ca2+ mobilization, with anxiolytic and anti-addictive properties.

Formula: C₃₂H₃₁ClN₄O₅

Purity: 97.51% - 99.44%

Color and Shape: Solid

Molecular weight: 587.07

Ref: TM-T16034

Meclinertant

Controlled Product

CAS: 146362-70-1

Formula: C₃₂H₃₁ClN₄O₅

Color and Shape: Neat

Molecular weight: 587.065

Ref: TR-M202690

Meclinertant

Controlled Product

CAS: 146362-70-1

Meclinertant (MT) is a neurotensin receptor antagonist that blocks the action of this neurotransmitter on its receptors in the brain and spinal cord. MT has been shown to block neurotensin receptor-mediated glutamate release, cytosolic calcium mobilization, and mitochondrial membrane potential changes in cells. The biological properties of MT have been shown to be useful in treating cancer and radiation-induced damage, as well as for reducing symptoms associated with Parkinson's disease. The pharmacological activity of MT may be due to inhibition of MMP-9 activity and locomotor activity.

Formula: C₃₂H₃₁ClN₄O₅

Purity: Min. 95%

Molecular weight: 587.07 g/mol

Ref: 3D-FM176816