CAS 146374-27-8

2-Methyl-2-propanesulfinamide

Description:

2-Methyl-2-propanesulfinamide, with the CAS number 146374-27-8, is an organic compound characterized by the presence of a sulfinamide functional group. It features a branched alkyl chain, specifically a tert-butyl group, which contributes to its steric hindrance and influences its reactivity. This compound is typically a colorless to pale yellow liquid or solid, depending on the temperature and purity. It is soluble in polar organic solvents, which makes it useful in various chemical reactions, particularly in the synthesis of pharmaceuticals and agrochemicals. The sulfinamide group imparts unique chemical properties, allowing it to participate in nucleophilic substitution reactions and serve as a potential building block in organic synthesis. Additionally, 2-Methyl-2-propanesulfinamide may exhibit specific biological activities, making it of interest in medicinal chemistry. Safety data should be consulted for handling and storage, as with any chemical substance, to ensure proper precautions are taken due to potential toxicity or reactivity.

Formula: C₄H₁₁NOS

InChI: InChI=1S/C4H11NOS/c1-4(2,3)7(5)6/h5H2,1-3H3

InChI key: InChIKey=CESUXLKAADQNTB-UHFFFAOYSA-N

SMILES: C(S(N)=O)(C)(C)C

Synonyms:

• 1,1-Dimethylethylsulfinamide
• 2-Methyl-2-Propanesulfinamide
• 2-Methyl-2-Propanesulfinamide, Racemic
• 2-Methyl-Propane-2-Sulfinic Acid Amide
• 2-Methylpropan-2-sulfinamide
• 2-Methylpropane-1-Sulfinamide
• 2-Propanesulfinamide, 2-methyl-
• Racemic Tert Butylsulfinamide
• T-Butylsulfinamide
• Tert-Butylsulfinamide
• Tert-Butylsulphinamide

tert-Butylsulfinamide

CAS: 146374-27-8

Formula: C₄H₁₁NOS

Purity: >97.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 121.20

Ref: 3B-B2926

(±)-2-Methyl-2-propanesulfinamide, 97%

CAS: 146374-27-8

()-2-Methyl-2-propanesulfinamide is used in the synthesis of 4-sulfonyliminopiperidine and its reaction with benzyl Grignard to form an important pharmaceutical building block, 4-benzyl-4-aminopiperidne. It is also used to prepare spiro tosylaziridines via methylene insertion into the derived sulfon

Formula: (CH₃)₃CS(O)NH₂

Purity: 97%

Color and Shape: Powder or crystalline powder or lumpy powder, White to cream to pale brown

Molecular weight: 121.2

Ref: 02-B25385

2-Propanesulfinamide, 2-methyl-

CAS: 146374-27-8

Formula: C₄H₁₁NOS

Purity: 97%

Color and Shape: Solid

Molecular weight: 121.2012

Ref: IN-DA00HXHN

t-Butylsulfinamide

CAS: 146374-27-8

Formula: C₄H₁₁NOS

Purity: 97%

Color and Shape: Solid, Powder

Molecular weight: 121.2

Ref: 10-F034514

2-Methylpropane-2-sulphinamide

CAS: 146374-27-8

2-Methylpropane-2-sulphinamide

Formula: C₄H₁₁NOS

Purity: 96%

Color and Shape: white solid

Molecular weight: 121.20g/mol

Ref: 54-OR301075

tert-Butylsulfinamide

Controlled Product

CAS: 146374-27-8

Applications tert-Butylsulfinamide can be readily transformed into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones, which can undergo iridium-catalyzed asymmetric hydrogenation of olefins. tert-Butylsulfinamide is also used as a reagent in the synthetic preparation of amide series as BACE1 inhibitor and potential anti-Alzheimer’s drug.
References Szallasi, A., et al.: Pharmacol. Rev., 51, 159 (1999), Montell, C., et al.: Mol. Cell., 9, 229 (2002), Ryu, C., et al.: Bioorg. Med. Chem. Lett., 14, 1751 (2004), Suh, Y., et al.: J. Med. Chem., 48, 5823 (2005); Woltering, T. J., et al.: Bioorg. Med. Chem. Lett., 23, 4239 (2013)

Formula: C₄H₁₁NOS

Color and Shape: Neat

Molecular weight: 121.2

Ref: TR-B693900

tert-Butylsulfinamide

CAS: 146374-27-8

tert-Butylsulfinamide is a model system for the synthesis of enantiopure amines and esters. The synthesis of tert-butylsulfinamide starts with the reaction of an allyl bromide with a sulfinic acid chloride to form an allyl sulfonate, which is then hydrolyzed to produce tert-butylsulfinamide. The yield for this type of reaction is usually low, but tert-butylsulfinamide can be isolated in good yields if it is prepared in a stereoselective manner. Tert-butylsulfinamide has been shown to inhibit the growth of human hair follicles in cell culture experiments, which may be due to its ability to inhibit the formation of hydrogen peroxide by inhibiting an enzyme called tyrosine hydroxylase.

Formula: C₄H₁₁NOS

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 121.2 g/mol

Ref: 3D-FB61266