CAS 146426-40-6: Alvocidib

Description: Alvocidib, also known by its chemical name, is a small molecule inhibitor primarily targeting cyclin-dependent kinases (CDKs), particularly CDK9. It is classified as an investigational drug and has been studied for its potential therapeutic applications in various cancers, particularly hematological malignancies. Alvocidib functions by disrupting the transcriptional regulation of genes essential for cell cycle progression and survival, leading to apoptosis in cancer cells. The compound is typically administered intravenously and has shown promise in combination therapies, enhancing the efficacy of other anticancer agents. Its mechanism of action involves the inhibition of RNA polymerase II phosphorylation, which is crucial for mRNA synthesis. Alvocidib has undergone clinical trials to evaluate its safety, tolerability, and effectiveness, although its use is still largely experimental. As with many targeted therapies, the development of resistance and the identification of biomarkers for patient selection are critical areas of ongoing research. Overall, Alvocidib represents a significant advancement in the field of targeted cancer therapy.

Formula: C₂₁H₂₀ClNO₅

InChI: InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1

InChI key: InChIKey=BIIVYFLTOXDAOV-YVEFUNNKSA-N

SMILES: O=C1C=C(OC=2C1=C(O)C=C(O)C2C3CCN(C)CC3O)C=4C=CC=CC4Cl

Synonyms:

• (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-1-benzopyran-4-one
• 2-(2-Chlorophenyl)-5,7-Dihydroxy-8-[(3S,4R)-3-Hydroxy-1-Methyl-4-Piperidyl]Chromen-4-One
• 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one
• 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one
• 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, cis-(-)-
• 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-
• Alvocidib
• Dsp 2033
• Flavopirodol
• Hl 275
• Hmr 1275
• L 86-8275
• L 868275
• Flavopiridol

4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-

CAS: 146426-40-6

• Formula: C₂₁H₂₀ClNO₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 401.8402

Flavopiridol

CAS: 146426-40-6

• Color and Shape: Solid
• Molecular weight: 401.84g/mol

Flavopiridol

CAS: 146426-40-6

• Purity: 97%
• Molecular weight: 401.84g/mol

Flavopiridol

CAS: 146426-40-6

Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; …

• Formula: C₂₁H₂₀ClNO₅
• Purity: 97.74% - 99.9%
• Color and Shape: Solid
• Molecular weight: 401.84

Alvocidib (Flavopiridol)

CAS: 146426-40-6

• Formula: C₂₁H₂₀ClNO₅
• Molecular weight: 401.84

Flavopiridol

CAS: 146426-40-6

Inhibitor of CKD1, CDK2, and CDK4 serine/threonine kinases

• Formula: C₂₁H₂₀ClNO₅
• Purity: Min. 95%
• Color and Shape: Light (Or Pale) Yellow To Yellow Solid
• Molecular weight: 401.103