CAS 146464-95-1: Pralatrexate

Description: Pralatrexate is a synthetic antifolate compound primarily used in the treatment of certain types of cancer, particularly peripheral T-cell lymphoma. It functions as an inhibitor of dihydrofolate reductase, an enzyme critical for DNA synthesis and cell proliferation. This mechanism disrupts the folate metabolism in rapidly dividing cancer cells, leading to their growth inhibition. Pralatrexate is characterized by its high affinity for the reduced folate carrier, which facilitates its uptake into cells. The compound is typically administered via intravenous injection and is known for its ability to penetrate tissues effectively. Its chemical structure includes a pteridine core, which is essential for its biological activity. Pralatrexate has been associated with various side effects, including myelosuppression, mucositis, and fatigue, necessitating careful monitoring during treatment. Overall, pralatrexate represents a targeted therapeutic approach in oncology, leveraging its biochemical properties to combat malignancies that are resistant to conventional therapies.

Formula: C₂₃H₂₃N₇O₅

InChI: InChI=1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t14?,16-/m0/s1

InChI key: InChIKey=OGSBUKJUDHAQEA-WMCAAGNKSA-N

SMILES: O=C(O)CCC(NC(=O)C1=CC=C(C=C1)C(CC#C)CC=2N=C3C(=NC2)N=C(N=C3N)N)C(=O)O

Synonyms:

• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butynyl]benzoyl]-
• Folotyn
• N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid
• N-[4-[1-[(2,4-Diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-{4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}-L-glutamic acid
• NSC 754230
• Pralatrexate
• L-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butynyl]benzoyl]-
• N-[4-[1-[(2,4-Diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-L-glutamic acid
• 10-Propargyl-10-deazaaminopterin
• L-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-
• PDX

L-Glutamic acid, N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-

CAS: 146464-95-1

• Formula: C₂₃H₂₃N₇O₅
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 477.4726

Pralatrexate

CAS: 146464-95-1

• Formula: C₂₃H₂₃N₇O₅
• Molecular weight: 477.47

Pralatrexate

CAS: 146464-95-1

• Purity: 99.59%
• Molecular weight: 477.47g/mol

(2S)-2-(4-(1-(2,4-Diaminopteridin-6-yl)Pent-4-yn-2-yl)Benzamido)Pentanedioic Acid

CAS: 146464-95-1

• Purity: 98%
• Molecular weight: 477.47g/mol

Pralatrexate-13C5-15N

CAS: 146464-95-1

• Formula: C₁₈₁₃C₅H₂₃N₆₁₅NO₅
• Color and Shape: Pale Yellow Solid
• Molecular weight: 483.44

Pralatrexate

CAS: 146464-95-1

Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for …

• Formula: C₂₃H₂₃N₇O₅
• Purity: 94.32% - 99.59%
• Color and Shape: Solid
• Molecular weight: 477.47

Pralatrexate

CAS: 146464-95-1

• Formula: C₂₃H₂₃N₇O₅
• Molecular weight: 477.48

Pralatrexate

CAS: 146464-95-1

Please enquire for more information about Pralatrexate including the price, delivery time and more detailed …

• Formula: C₂₃H₂₃N₇O₅
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 477.47 g/mol

Pralatrexate-13C5

CAS: 146464-95-1

Applications Pralatrexate-15C5 is labelled Pralatrexate (P700500) which is an antifolate with high affinity for the …

• Formula: C₁₈C₅H₂₃N₇O₅
• Color and Shape: Neat
• Molecular weight: 492.472