CAS 146533-41-7

5-(4-Bromophenyl)-4,6-dichloropyrimidine

Description:

5-(4-Bromophenyl)-4,6-dichloropyrimidine is a heterocyclic organic compound characterized by a pyrimidine ring substituted with both bromine and chlorine atoms. The presence of the 4-bromophenyl group indicates that there is a bromine atom attached to a phenyl ring, which is further connected to the pyrimidine structure. This compound typically exhibits properties such as moderate to high solubility in organic solvents, and its molecular structure suggests potential reactivity due to the halogen substituents, which can influence its chemical behavior and interactions. The dichloropyrimidine moiety may impart biological activity, making it of interest in pharmaceutical research and development. Additionally, the compound's unique arrangement of halogens can affect its electronic properties, potentially leading to applications in materials science or as a precursor in organic synthesis. Safety data should be consulted for handling, as halogenated compounds can pose environmental and health risks.

Formula: C₁₀H₅BrCl₂N₂

InChI: InChI=1S/C10H5BrCl2N2/c11-7-3-1-6(2-4-7)8-9(12)14-5-15-10(8)13/h1-5H

InChI key: InChIKey=WEEFLZORZXLIJE-UHFFFAOYSA-N

SMILES: ClC=1C(=C(Cl)N=CN1)C2=CC=C(Br)C=C2

Synonyms:

• 4,6-Dichloro-5-(4-Bromophenyl)Pyrimidine
• 5-(4-Bromophenyl)-4,6-dichloro-1,3-diazine
• 5-(4-Bromophenyl)-4,6-dichloropyrimidine
• PyriMidine, 5-(4-broMophenyl)-4,6-dichloro-

5-(4-Bromophenyl)-4,6-dichloropyrimidine

CAS: 146533-41-7

Formula: C₁₀H₅BrCl₂N₂

Purity: >98.0%(GC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 303.97

Ref: 3B-B4950

5-(4-BROMOPHENYL)-4,6-DICHLOROPYRIMIDINE

CAS: 146533-41-7

Formula: C₁₀H₅BrCl₂N₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 303.9701

Ref: IN-DA001E4G

Macitentan Impurity 44

CAS: 146533-41-7

Formula: C₁₀H₅BrCl₂N₂

Molecular weight: 303.97

Ref: 4Z-M-128049

5-(4-Bromophenyl)-4,6-dichloropyrimidine

CAS: 146533-41-7

5-(4-Bromophenyl)-4,6-dichloropyrimidine

Formula: C₁₀H₅BrCl₂N₂

Purity: 98%

Color and Shape: faint brown to dark brown solid

Molecular weight: 303.97g/mol

Ref: 54-OR46538

Macitentan KSM-I Impurity

CAS: 146533-41-7

Formula: C₁₀H₅BrCl₂N₂

Molecular weight: 303.977

Ref: ST-EA-CP-M5003

5-(4-Bromophenyl)-4,6-dichloropyrimidine

CAS: 146533-41-7

Formula: C₁₀H₅BrCl₂N₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 303.97

Ref: 10-F462071

5-(4-Bromophenyl)-4,6-dichloropyrimidine

Controlled Product

CAS: 146533-41-7

Applications 5-(4-Bromophenyl)-4,6-dichloropyrimidine is a reactant used in the synthesis of Macitentan, an orally active dual endothelin receptor antagonist.
References Bolli, M. et al.: J. Med. Chem., 55, 7849 (2012);

Formula: C₁₀H₅BrCl₂N₂

Color and Shape: Neat

Molecular weight: 303.97

Ref: TR-B687865