CAS 146535-11-7

tyrphostin ag 1296

Description:

Tyrphostin AG 1296 is a selective inhibitor of the protein tyrosine kinase activity, specifically targeting the platelet-derived growth factor (PDGF) receptor. This compound is known for its role in research related to cell signaling pathways, particularly in the context of cancer and cellular proliferation. It exhibits characteristics typical of small organic molecules, including a relatively low molecular weight and the ability to penetrate cell membranes, which facilitates its action within cells. Tyrphostin AG 1296 has been utilized in various studies to investigate the effects of tyrosine kinase inhibition on cellular processes such as growth, differentiation, and migration. Its mechanism of action involves blocking the phosphorylation of tyrosine residues, which is crucial for the activation of signaling cascades that promote cell division and survival. As a research tool, it has contributed to a better understanding of the role of tyrosine kinases in disease mechanisms, particularly in oncology and developmental biology. However, like many chemical inhibitors, its use is primarily confined to laboratory settings and requires careful handling due to potential biological activity.

Formula: C₁₆H₁₄N₂O₂

InChI: InChI=1/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3

SMILES: COc1cc2c(cc1OC)nc(cn2)c1ccccc1

Synonyms:

• Ag 1296
• 6,7-Dimethoxy-2-Phenylquinoxaline

Quinoxaline, 6,7-dimethoxy-2-phenyl-

CAS: 146535-11-7

Formula: C₁₆H₁₄N₂O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 266.2946

Ref: IN-DA001E48

Tyrphostin AG 1296

CAS: 146535-11-7

Formula: C₁₆H₁₄N₂O₂

Molecular weight: 266.29

Ref: 7W-GK5393

6,7-Dimethoxy-2-Phenylquinoxaline

CAS: 146535-11-7

6,7-Dimethoxy-2-Phenylquinoxaline

Purity: 99%

Molecular weight: 266.29g/mol

Ref: 54-OR1011967

Tyrphostin AG1296

CAS: 146535-11-7

Tyrphostin AG1296

Purity: ≥98%

Molecular weight: 266.29g/mol

Ref: 54-BUP15372

AG-1296

CAS: 146535-11-7

Formula: C₁₆H₁₄N₂O₂

Purity: >98.0%(GC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 266.30

Ref: 3B-D4601

Tyrphostin AG1296

CAS: 146535-11-7

Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.

Formula: C₁₆H₁₄N₂O₂

Purity: 99.94% - >99.99%

Color and Shape: Solid

Molecular weight: 266.29

Ref: TM-T6711

Tyrphostin AG 1296

Controlled Product

CAS: 146535-11-7

Applications Tyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.
References Watanabe, T. et al.: J. Neuro. 118, 838 (2013);

Formula: C₁₆H₁₄N₂O₂

Color and Shape: Neat

Molecular weight: 266.295

Ref: TR-T923505