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CAS 146623-69-0

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Saprisartan

Description:
Saprisartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It belongs to the class of medications known as sartans, which function by blocking the action of angiotensin II, a hormone that constricts blood vessels and increases blood pressure. The chemical structure of Saprisartan includes a biphenyl moiety and a carboxylic acid group, contributing to its pharmacological activity. It is characterized by its ability to selectively inhibit the AT1 receptor, leading to vasodilation and reduced blood pressure. Saprisartan is typically administered orally and has a favorable pharmacokinetic profile, including good bioavailability and a relatively long half-life, allowing for once-daily dosing. Additionally, it may exhibit some degree of renal protective effects, making it beneficial for patients with certain comorbid conditions. As with other medications in its class, potential side effects may include dizziness, hypotension, and renal impairment, necessitating monitoring during treatment. Overall, Saprisartan represents an important therapeutic option in the management of hypertension.
Formula:C25H22BrF3N4O4S
InChI:InChI=1S/C25H22BrF3N4O4S/c1-2-19-31-21(14-8-9-14)22(24(30)34)33(19)12-13-7-10-18-16(11-13)20(26)23(37-18)15-5-3-4-6-17(15)32-38(35,36)25(27,28)29/h3-7,10-11,14,32H,2,8-9,12H2,1H3,(H2,30,34)
InChI key:InChIKey=DUEWVPTZCSAMNB-UHFFFAOYSA-N
SMILES:C(N)(=O)C1=C(N=C(CC)N1CC=2C=C3C(=CC2)OC(=C3Br)C4=C(NS(C(F)(F)F)(=O)=O)C=CC=C4)C5CC5
Synonyms:
  • 1-[[3-Bromo-2-[2-[[(trifluoromethyl)sulfonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxamide
  • Saprisartan
  • 1H-Imidazole-5-carboxamide, 1-[[3-bromo-2-[2-[[(trifluoromethyl)sulfonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-cyclopropyl-2-ethyl-
  • GR 138950
  • Saprisartan [INN:BAN]
  • 1-{[3-bromo-2-(2-{[(trifluoromethyl)sulfonyl]amino}phenyl)-1-benzofuran-5-yl]methyl}-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxamide
  • GR-138950X
  • GR138950
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Found 2 products.
  • Saprisartan
    Targetmol
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    Saprisartan

    CAS:
    Saprisartan (GR-138950, GR-138950X) is an AT1 receptor antagonist used for the treatment of heart failure and blood pressure.
    Formula:C25H22BrF3N4O4S
    Color and Shape:Solid
    Molecular weight:611.43

    Ref: TM-T34518

    25mg
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    50mg
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    100mg
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  • Saprisartan
    TRC
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    Saprisartan

    Controlled Product
    CAS:
    Formula:C25H22BrF3N4O4S
    Color and Shape:Neat
    Molecular weight:611.431

    Ref: TR-S117000

    50mg
    23,991.00€