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CAS 14663-23-1

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Dantrolene sodium

Description:
Dantrolene sodium is a muscle relaxant primarily used in the treatment of conditions such as malignant hyperthermia and spasticity associated with neurological disorders. It functions by inhibiting calcium release from the sarcoplasmic reticulum of skeletal muscle, thereby reducing muscle contraction. This compound is a white to off-white crystalline powder that is soluble in water and has a pH range that is typically neutral to slightly alkaline. Dantrolene sodium is administered intravenously or orally, depending on the clinical scenario. Its chemical structure includes a dantrolene moiety, which is a derivative of hydantoin, and it is often formulated as the sodium salt to enhance solubility. The pharmacokinetics of dantrolene involve hepatic metabolism, and it is important to monitor liver function during prolonged therapy due to potential hepatotoxicity. Overall, dantrolene sodium is a critical medication in emergency and chronic care settings, requiring careful dosing and monitoring to ensure patient safety and efficacy.
Formula:C14H10N4O5·Na
InChI:InChI=1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);
InChI key:InChIKey=BDZCLIOURDFSFQ-UHFFFAOYSA-N
SMILES:C(=NN1CC(=O)NC1=O)C=2OC(=CC2)C3=CC=C(N(=O)=O)C=C3.[Na]
Synonyms:
  • 1-[5-(-4-Nitrophenyl)furfurylideneamino]imidazolidine-2,4-dione sodium
  • 1-[[5-(p-Nitrophenyl)furfurylidene]amino]-hydantoin sodium salt
  • 2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt
  • 2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt (1:1)
  • 2,4-imidazolidinedione, 1-[[(1E)-[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt
  • Dantrium
  • Dantrolene Na
  • Dantrolene, Sodium Salt
  • F 440
  • Hydantoin, 1-[[5-(p-nitrophenyl)furfurylidene]amino]-, sodium salt
  • See more synonyms
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