CAS 14663-23-1

Dantrolene sodium

Description:

Dantrolene sodium is a muscle relaxant primarily used in the treatment of conditions such as malignant hyperthermia and spasticity associated with neurological disorders. It functions by inhibiting calcium release from the sarcoplasmic reticulum of skeletal muscle, thereby reducing muscle contraction. This compound is a white to off-white crystalline powder that is soluble in water and has a pH range that is typically neutral to slightly alkaline. Dantrolene sodium is administered intravenously or orally, depending on the clinical scenario. Its chemical structure includes a dantrolene moiety, which is a derivative of hydantoin, and it is often formulated as the sodium salt to enhance solubility. The pharmacokinetics of dantrolene involve hepatic metabolism, and it is important to monitor liver function during prolonged therapy due to potential hepatotoxicity. Overall, dantrolene sodium is a critical medication in emergency and chronic care settings, requiring careful dosing and monitoring to ensure patient safety and efficacy.

Formula: C₁₄H₁₀N₄O₅·Na

InChI: InChI=1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);

InChI key: InChIKey=BDZCLIOURDFSFQ-UHFFFAOYSA-N

SMILES: C(=NN1CC(=O)NC1=O)C=2OC(=CC2)C3=CC=C(N(=O)=O)C=C3.[Na]

Synonyms:

• 1-[5-(-4-Nitrophenyl)furfurylideneamino]imidazolidine-2,4-dione sodium
• 1-[[5-(p-Nitrophenyl)furfurylidene]amino]-hydantoin sodium salt
• 2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt
• 2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt (1:1)
• 2,4-imidazolidinedione, 1-[[(1E)-[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt
• Dantrium
• Dantrolene Na
• Dantrolene, Sodium Salt
• F 440
• Hydantoin, 1-[[5-(p-nitrophenyl)furfurylidene]amino]-, sodium salt
• Ryanodex
• Sodium 3-({[5-(4-Nitrophenyl)Furan-2-Yl]Methylidene}Amino)-2,5-Dioxoimidazolidin-1-Ide
• Sodium dantrolene
• sodium 1-({(1E)-[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)-4-oxo-4,5-dihydro-1H-imidazol-2-olate

Dantrolene sodium salt

CAS: 14663-23-1

Inhibits intracellular calcium release from the sarcoplasmic reticulum

Formula: C₁₄H₉N₄NaO₅

Molecular weight: 336.23

Ref: 02-J60887

Dantrolene sodium

CAS: 14663-23-1

Dantrolene sodium

Formula: C₁₄H₉N₄NaO₅

Purity: 92.2%

Color and Shape: Light Orange Colour

Molecular weight: 336.04706

Ref: 47-771

Dantrolene sodium

CAS: 14663-23-1

Dantrolene sodium treats spasticity by disrupting muscle contraction; not central in action, grouped with central relaxants.

Formula: C₁₄H₉N₄NaO₅

Purity: 98% - 99.87%

Color and Shape: Coa

Molecular weight: 336.23

Ref: TM-T0077

2,​4-​Imidazolidinedione, 1-​[[[5-​(4-​nitrophenyl)​-​2-​furanyl]​methylene]​amino]​-​, sodium salt (1:1)

CAS: 14663-23-1

Formula: C₁₄H₁₀N₄NaO₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 337.2428

Ref: IN-DA003P8O

Dantrolene sodium

CAS: 14663-23-1

Dantrolene sodium

Purity: ≥98%

Molecular weight: 336.23g/mol

Ref: 54-BUP14980

Sodium 3-(((5-(4-Nitrophenyl)Furan-2-Yl)Methylene)Amino)-2,5-Dioxoimidazolidin-1-Ide

CAS: 14663-23-1

Sodium 3-(((5-(4-Nitrophenyl)Furan-2-Yl)Methylene)Amino)-2,5-Dioxoimidazolidin-1-Ide

Purity: 98%

Molecular weight: 336.23g/mol

Ref: 54-OR1014972

Dantrolene sodium salt, USP grade

CAS: 14663-23-1

Formula: C₁₄H₉N₄NaO₅·xH₂O

Purity: 98.0 - 102.0 % (anhydrous basis)

Color and Shape: Orange to dark orange crystalline powder

Molecular weight: 336.23 (anhydrous)

Ref: 7W-GP9837

Dantrolene sodium salt

CAS: 14663-23-1

Formula: C₁₄H₉N₄NaO₅·xH₂O

Purity: ≥ 98.0% (anhydrous basis)

Color and Shape: Orange to dark orange crystalline powder

Molecular weight: 336.23 (anhydrous)

Ref: 7W-GP0222

Dantrolene Sodium Salt

CAS: 14663-23-1

Formula: C₁₄H₉N₄O₅·Na

Molecular weight: 313.25 22.99

Ref: 4Z-D-2711

1-[[5-(p-Nitrophenyl)furfurylidene]amino]-hydantoin sodium

CAS: 14663-23-1

Dantrolene sodium is a muscle relaxant that belongs to the group of pharmacological agents. It is used to treat muscle spasms and hyperactivity in patients with neuromuscular disorders. Dantrolene sodium inhibits calcium release by blocking the activity of the enzyme ryanodine receptor in skeletal muscle cells. This inhibition prevents uncontrolled contraction of muscles and reduces their energy consumption. The drug also has an effect on malignant hyperthermia, which is caused by an increase in the production of adenosine triphosphate (ATP) due to increased cellular metabolism. Dantrolene sodium can inhibit ATP synthesis, thus reducing energy production and stabilizing cell membranes, thereby preventing cell death in neurons and other tissues.

Formula: C₁₄H₁₀N₄O₅•Na

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 337.24 g/mol

Ref: 3D-FN44999

Dantrolene Sodium Salt Hydrate

CAS: 14663-23-1, 7261-97-4

Formula: C₁₄H₉N₄NaO₅·xH₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: Orange to Brown powder to crystal

Molecular weight: 336.24 (as Anhydrous)

Ref: 3B-D3996

Dantrolene Sodium

CAS: 14663-23-1

Formula: C₁₄H₉N₄O₅Na

Molecular weight: 313.25 : 23

Ref: ST-EA-CP-D103010