CAS 146663-67-4

dutomycin

Description:

Dutomycin is a chemical compound classified as an antibiotic, specifically belonging to the class of macrolide antibiotics. It is produced by the fermentation of certain strains of Streptomyces bacteria. Dutomycin exhibits antibacterial properties, primarily targeting Gram-positive bacteria, and is known for its mechanism of action that involves inhibiting protein synthesis by binding to the bacterial ribosome. The compound has a complex molecular structure, characterized by a large lactone ring, which is typical of macrolides. Its pharmacological profile includes potential applications in treating various bacterial infections, although its clinical use may be limited compared to other antibiotics due to resistance issues or side effects. Additionally, dutomycin's solubility, stability, and bioavailability are important factors that influence its therapeutic efficacy. As with many antibiotics, careful consideration of its use is essential to mitigate the risk of developing antibiotic resistance. Overall, dutomycin represents a significant area of interest in the field of medicinal chemistry and antibiotic development.

Formula: C₄₄H₅₄O₁₇

InChI: InChI=1/C44H54O17/c1-10-11-18(2)14-19(3)41(52)61-39-23(7)58-29(17-42(39,8)53)59-26-12-13-28(57-22(26)6)60-40-36(49)31(21(5)45)37(50)44(55)38(51)32-24(16-43(40,44)54)20(4)30-33(35(32)48)25(46)15-27(56-9)34(30)47/h14-15,18,22-23,26,28-29,39-40,48,50,53-55H,10-13,16-17H2,1-9H3/b19-14-/t18-,22-,23+,26+,28+,29+,39-,40-,42-,43-,44-/m1/s1

Synonyms:

• 1,4,6,7(6aH,10H)-Naphthacenetetrone, 8-acetyl-10-((5-((2,6-dideoxy-4-O-(2,4-dimethyl-1-oxo-2-heptenyl)-3-C-methyl-alpha-L-xylo-hexopyranosyl)oxy)tetrahydro-6-methyl-2H-pyran-2-yl)oxy)-10a,11-dihydro-5,6a,9,10a-tetrahydroxy-2-methoxy-12-methyl-, (2S-(2alpha(6aR*,10S*,10aS*),5beta(2Z,4S*),6alpha))-
• (2R,3S,6S)-6-{[(1S,4aS,12aR)-3-acetyl-4,4a,6,12a-tetrahydroxy-9-methoxy-11-methyl-2,5,7,10-tetraoxo-1,2,4a,5,7,10,12,12a-octahydrotetracen-1-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl 2,6-dideoxy-4-O-[(2Z,4R)-2,4-dimethylhept-2-enoyl]-3-C-methyl-α-L-xylo-hexopyranoside
• Dutomycin

Dutomycin

CAS: 146663-67-4

Dutomycin is a SERPINB6 inhibitor with a binding constant (KD) of 1.236 μM. It can induce autophagy and apoptosis in cancer cells and suppresses the growth of cancer cells in zebrafish xenotransplant models. Dutomycin holds potential for cancer research.

Formula: C₄₄H₅₄O₁₇

Color and Shape: Solid

Molecular weight: 854.889

Ref: TM-TN9836