CAS 146665-77-2

Eptaplatin

Description:

Eptaplatin is a platinum-based chemotherapeutic agent that belongs to the class of drugs known as alkylating agents. It is primarily characterized by its ability to form DNA cross-links, which disrupts the replication and transcription processes in cancer cells, ultimately leading to cell death. Eptaplatin is designed to target various types of tumors, including those resistant to other platinum compounds. Its chemical structure includes a platinum center coordinated with various ligands, which enhances its efficacy and alters its pharmacokinetic properties compared to other platinum drugs like cisplatin and carboplatin. The compound has been studied for its potential in treating solid tumors and has shown promise in clinical trials. However, like many chemotherapeutic agents, eptaplatin may also exhibit side effects, including myelosuppression, nephrotoxicity, and gastrointestinal disturbances. Ongoing research continues to evaluate its effectiveness and safety profile in various cancer treatment regimens.

Formula: C₁₁H₂₀N₂O₆Pt

InChI: InChI=1S/C8H18N2O2.C3H4O4.Pt/c1-5(2)8-11-6(3-9)7(4-10)12-8;4-2(5)1-3(6)7;/h5-8H,3-4,9-10H2,1-2H3;1H2,(H,4,5)(H,6,7);/q;;+2/p-2/t6-,7-;;/m1../s1

InChI key: InChIKey=XJXKGUZINMNEDK-GPJOBVNKSA-L

SMILES: O=C1[O-][Pt+2]2([O-]C(=O)C1)[NH2]C[C@@]3([C@@](C[NH2]2)(O[C@H]([C@@H](C)C)O3)[H])[H]

Synonyms:

• Heptaplatin
• Platinum, [(4R,5R)-2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-κN⁴,κN⁵][propanedioato(2-)-κO¹,κO³]-, (SP-4-2)-
• Platinum, [2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-N,N′][propanedioato(2-)-O,O′]-, [SP-4-2-[4R-(2α,4α,5β)]]-
• Platinum, [2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-κN⁴,κN⁵][propanedioato(2-)-κO¹,κO³]-, [SP-4-2-[4R-(2α,4α,5β)]]-
• Ski 2053R
• Sunpla
• [Sp-4-2-[4R-(2a,4a,5b)]]-[2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-n,n'][propanedioato(2-)-o,o']-platinum
• platinum(2+) propanedioate [(4R,5R)-2-(propan-2-yl)-1,3-dioxolane-4,5-diyl]dimethanamine (1:1:1)
• Platinum, [(4R,5R)-2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-κN4,κN5][propanedioato(2-)-κO1,κO3]-, (SP-4-2)-
• Platinum, [2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-κN4,κN5][propanedioato(2-)-κO1,κO3]-, [SP-4-2-[4R-(2α,4α,5β)]]-
• Eptaplatin

Heptaplatin (Sunpla)

CAS: 146665-77-2

Formula: C₁₁H₂₀N₂O₆Pt

Purity: 98%

Color and Shape: Solid

Molecular weight: 471.3643

Ref: IN-DA00HXII

Heptaplatin

CAS: 146665-77-2

Heptaplatin, an anticancer platinum compound, counters many cancers, including cisplatin-resistant types, with a 17% response rate and tolerable toxicity.

Formula: C₁₁H₂₀N₂O₆Pt

Color and Shape: White Crystalline Powder

Molecular weight: 471.36

Ref: TM-T21307

Eptaplatin

CAS: 146665-77-2

Platinum-based anti-tumor drug

Formula: C₁₁H₂₀N₂O₆Pt

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 471.37 g/mol

Ref: 3D-FE22772

Eptaplatin

Controlled Product

CAS: 146665-77-2

Applications A coordination compound for treatment of cervix cancer.
References Jiang, M., et al.: Methods Mol. Biol., 292, 401 (2005), Fujii, T., et al.: Int. J. Oncol., 29, 541 (2006), Niu, X., et al.: Int. J. Gynecol. Cancer, 16, 743 (2006),

Formula: C₈H₁₈N₂O₂·C₃H₂O₄Pt

Color and Shape: Neat

Molecular weight: 471.36

Ref: TR-E591500