CAS 146709-78-6

5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE

Description:

5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride, with CAS number 146709-78-6, is a synthetic organic compound characterized by its complex structure, which includes a naphthyridine core, a biphenyl moiety, and a tetrazole group. This compound typically exhibits properties such as solubility in polar solvents and potential bioactivity, making it of interest in medicinal chemistry. Its molecular structure suggests it may interact with biological targets, possibly influencing pathways related to cardiovascular or neurological functions. The presence of the tetrazole ring may enhance its pharmacological properties, including increased lipophilicity and metabolic stability. As a hydrochloride salt, it is likely to be more soluble in aqueous environments, facilitating its use in pharmaceutical formulations. Overall, this compound represents a class of heterocyclic compounds that may have therapeutic applications, although specific biological activities and mechanisms would require further investigation through experimental studies.

Formula: C₂₆H₂₇ClN₆O

InChI: InChI=1/C26H26N6O.ClH/c1-3-19-15-24-22(23(4-2)27-19)13-14-25(33)32(24)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)26-28-30-31-29-26;/h5-12,15H,3-4,13-14,16H2,1-2H3,(H,28,29,30,31);1H

SMILES: CCc1cc2c(CCC(=O)N2Cc2ccc(cc2)c2ccccc2c2n[nH]nn2)c(CC)n1.Cl

Synonyms:

• Zd 7155 Hydrochloride
• 5,7-Diethyl-3,4-dihydro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-onehydrochloride
• ZD7155HCl
• 5,7-diethyl-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride

1,6-Naphthyridin-2(1H)-one, 5,7-diethyl-3,4-dihydro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, hydrochloride (1:1)

CAS: 146709-78-6

Formula: C₂₆H₂₇ClN₆O

Purity: 97%

Color and Shape: Solid

Molecular weight: 474.9852

Ref: IN-DA001E8Y

ZD 7155 hydrochloride

CAS: 146709-78-6

ZD 7155 hydrochloride

Purity: ≥98%

Molecular weight: 474.98g/mol

Ref: 54-BUP04486

ZD 7155 hydrochloride

CAS: 146709-78-6

ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.

Formula: C₂₆H₂₇ClN₆O

Purity: 99.8%

Color and Shape: Solid

Molecular weight: 474.98

Ref: TM-T13390

ZD7155 hydrochloride

CAS: 146709-78-6

ZD7155 hydrochloride is a selective antagonist of the AT1 receptor (AT1R). It blocks the binding of angiotensin to the AT1 receptor and prevents activation of downstream signaling pathways. ZD7155 hydrochloride has been shown to inhibit whole-cell mediated responses in cultured rat cardiomyocytes, and specifically inhibits cell factor-dependent tyrosine kinase activity and subsequent angiotensin II-mediated phosphorylation of focal adhesion kinase. The drug also inhibits IL10-induced signal transduction, which may be due to its antagonistic effects on IL10 receptor.

Formula: C₂₆H₂₆N₆O·HCl

Purity: Min. 95%

Molecular weight: 474.99 g/mol

Ref: 3D-WFA70978