CAS 146764-24-1

4-HYDROXY NONENAL MERCAPTURIC ACID

Description:

4-Hydroxy nonenal mercapturic acid is a metabolite derived from the conjugation of 4-hydroxy-2-nonenal (4-HNE), a reactive aldehyde formed during lipid peroxidation, with glutathione. This compound is characterized by its mercapturic acid structure, which typically includes a cysteine-derived moiety that facilitates its excretion from the body. It serves as a biomarker for oxidative stress and lipid peroxidation, indicating cellular damage and potential involvement in various pathological conditions. The presence of this compound in biological samples can provide insights into the extent of oxidative damage and the body's detoxification processes. Its analysis is often performed using advanced techniques such as liquid chromatography coupled with mass spectrometry (LC-MS), allowing for sensitive detection in complex biological matrices. Understanding the levels of 4-hydroxy nonenal mercapturic acid can be crucial in research related to diseases linked to oxidative stress, including neurodegenerative disorders and cancer.

Formula: C₁₄H₂₅NO₅S

Synonyms:

• N-Acetyl-S-(Tetrahydro-5-Hydroxy-2-Pentyl-3-Furanyl)-L-Cysteine
• 4-HYDROXY NONENAL MERCAPTURIC ACID
• (2R)-2-Acetamido-3-((5-hydroxy-2-pentyltetrahydrofuran-3-yl)thio)propanoic acid
• L-Cysteine, N-acetyl-S-(tetrahydro-5-hydroxy-2-pentyl-3-furanyl)-
• DEWNQQSQBYUUAE-DCNVRKPOSA-N
• 4-hydroxy Nonenal Mercapturic Acid Exclusive

4-Hydroxy Nonenal Acetylcysteine (Mixture of Diastereomers)

CAS: 146764-24-1

Formula: C₁₄H₂₅NO₅S

Molecular weight: 319.42

Ref: 4Z-A-336033

4-hydroxy Nonenal Mercapturic Acid

CAS: 146764-24-1

Peroxidation of ω-6 PUFAs produces 4-HNE, which is rapidly cleared and excreted, mostly as urine metabolites, within 48h in rats.

Formula: C₁₄H₂₅NO₅S

Color and Shape: Solid

Molecular weight: 319.42

Ref: TM-T35971

4-Hydroxy Nonenal Mercapturic Acid-d3

Controlled Product

CAS: 146764-24-1

Applications 4-Hydroxy Nonenal Mercapturic Acid-d3, is a labeled analogue of 4-Hydroxy Nonenal Mercapturic Acid (H296810), a mercapturic acid conjugate of 4-hydroxy nonenal (4-HNE) formed to clear 4-HNE from plasma via enterohepatic circulation.
References Alary, J., et al., Chemical research in toxicology. 8(1): 34-9. PMID: 7703364;

Formula: C₁₄D₃H₂₂NO₅S

Color and Shape: Off-White To Light Green

Molecular weight: 322.435

Ref: TR-H296812