CAS 146943-43-3

(S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate

Description:

(S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate, with CAS number 146943-43-3, is a complex organic compound characterized by its multi-functional structure. It features a pyrrolopyrimidine core, which is known for its biological activity, particularly in medicinal chemistry. The presence of diethyl ester groups indicates that it has potential for solubility in organic solvents, making it suitable for various chemical reactions and applications. The compound also contains an amino group, which may contribute to its reactivity and potential interactions with biological targets. Its benzamide moiety suggests possible interactions with aromatic systems, enhancing its pharmacological properties. Overall, this compound's intricate structure and functional groups suggest it may have applications in drug development, particularly in targeting specific biological pathways or mechanisms. However, detailed studies would be necessary to fully elucidate its properties, including its stability, reactivity, and biological activity.

Formula: C₂₄H₂₉N₅O₆

Synonyms:

• N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester
• (s)-diethyl-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido) pentanedioate

Pemetrexed-d5 Diethyl Ester

Controlled Product

CAS: 146943-43-3

Applications Isotope labelled Pemetrexed-d5 Diethyl Ester is an protected intermediate in the synthesis of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes.
References Kjell, D.P., et al.: Org. Proc. Res. Development., 9, 738 (2005); Taylor, E. C., et al.: J. Org. Chem., 66, 3726 (2001);

Formula: C₂₄D₅H₂₄N₅O₆

Color and Shape: Neat

Molecular weight: 488.548

Ref: TR-P219512

Pemetrexed Diethyl Ester

Controlled Product

CAS: 146943-43-3

Applications Pemetrexed Diethyl Ester is an protected intermediate in the synthesis of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes.
References Kjell, D.P., et al.: Org. Proc. Res. Development., 9, 738 (2005); Taylor, E. C., et al.: J. Org. Chem., 66, 3726 (2001);

Formula: C₂₄H₂₉N₅O₆

Color and Shape: Neat

Molecular weight: 483.52

Ref: TR-P219510

Pemetrexed Diethyl Ester

CAS: 146943-43-3

Pemetrexed Diethyl Ester: precursor for Pemetrexed synthesis, blocks thymidylate synthase and folate-dependent enzymes.

Formula: C₂₄H₂₉N₅O₆

Color and Shape: Solid

Molecular weight: 483.52

Ref: TM-T70583