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CAS 146954-75-8

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5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Description:
5'-O-(4,4-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is a specialized chemical compound primarily used in the field of nucleic acid chemistry, particularly for the synthesis of oligonucleotides. This compound features a modified nucleoside, incorporating a fluorine atom at the 2' position of the deoxyribose sugar, which can enhance the stability and binding properties of the resulting oligonucleotides. The presence of the 4,4-dimethoxytrityl group serves as a protective moiety, allowing for selective deprotection during the synthesis process. The phosphoramidite functionality is crucial for the stepwise addition of nucleotides in automated synthesizers, facilitating the formation of phosphodiester bonds. Additionally, the cyanoethyl group contributes to the stability of the phosphoramidite, making it suitable for use in various chemical reactions. Overall, this compound is significant in the development of therapeutic oligonucleotides and in research applications involving RNA and DNA manipulation.
Formula:C39H46FN4O8P
Synonyms:
  • 5'-O-DMT-2'-F-dU-3'-CEDPA
  • 2'-F-dU Phosphoraamidite
  • 2'-Fluoro-5'-O-DMT-2'-deoxyuridine-3'-CE-Phosphoramidite
  • DMT-2-F-dU-CE Phosphoramidite
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