CAS 146954-76-9

N-Benzoyl-2′-deoxy-2′-fluorocytidine

Description:

N-Benzoyl-2′-deoxy-2′-fluorocytidine is a synthetic nucleoside analog characterized by the presence of a benzoyl group and a fluorine atom at the 2′ position of the deoxyribose sugar moiety. This compound is notable for its potential applications in antiviral and anticancer therapies, as it can interfere with nucleic acid synthesis. The fluorine substitution enhances its stability and bioavailability compared to natural nucleosides. The benzoyl group contributes to its lipophilicity, which may facilitate cellular uptake. N-Benzoyl-2′-deoxy-2′-fluorocytidine is typically studied for its mechanism of action, which involves incorporation into DNA, leading to chain termination during replication. Its chemical structure allows for interactions with various enzymes involved in nucleic acid metabolism, making it a subject of interest in medicinal chemistry. As with many nucleoside analogs, the pharmacokinetics and toxicity profiles are critical for evaluating its therapeutic potential. Overall, this compound exemplifies the strategic modifications made to nucleosides to enhance their pharmacological properties.

Formula: C₁₆H₁₆FN₃O₅

InChI: InChI=1S/C16H16FN3O5/c17-12-13(22)10(8-21)25-15(12)20-7-6-11(19-16(20)24)18-14(23)9-4-2-1-3-5-9/h1-7,10,12-13,15,21-22H,8H2,(H,18,19,23,24)/t10-,12-,13-,15-/m1/s1

InChI key: InChIKey=RHCOKFXBQWNMHE-BPGGGUHBSA-N

SMILES: F[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(NC(=O)C3=CC=CC=C3)C=C2

Synonyms:

• Cytidine, N-benzoyl-2′-deoxy-2′-fluoro-
• N4-Benzoyl-2'-deoxy-2'-fluorocytidine
• N6-Bz-2'-F-dC
• N-Benzoyl-2′-deoxy-2′-fluorocytidine

Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-

CAS: 146954-76-9

Formula: C₁₆H₁₆FN₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 349.3137

Ref: IN-DA001EHD

N-Benzoyl-2′-deoxy-2′-fluorocytidine

CAS: 146954-76-9

N-Benzoyl-2′-deoxy-2′-fluorocytidine

Purity: 98%

Ref: 54-PC1001892

N4-Benzoyl-2'-deoxy-2'-fluorocytidine

CAS: 146954-76-9

N4-Benzoyl-2'-deoxy-2'-fluorocytidine is a novel, synthetic nucleoside that has been shown to inhibit the growth of cancer cells and is being investigated as a potential anticancer drug. N4-Benzoyl-2'-deoxy-2'-fluorocytidine has also been found to be active against HIV, Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2), and influenza A virus. It prevents the replication of viruses by inhibiting DNA synthesis in the host cell.

Formula: C₁₆H₁₆FN₃O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 349.31 g/mol

Ref: 3D-NB57534