CAS 146954-77-0

Cytidine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro-

Description:

Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro- is a modified nucleoside that features a cytidine base with specific chemical modifications. This compound includes a benzoyl group, which enhances its lipophilicity and may influence its biological activity. The presence of the 5'-O-bis(4-methoxyphenyl)phenylmethyl group suggests that it has been designed for improved stability or selectivity in biochemical applications. The 2'-deoxy-2'-fluoro modification indicates that it is a fluorinated derivative of deoxycytidine, which can affect its interaction with nucleic acids and enzymes, potentially enhancing its therapeutic properties. Such modifications are often employed in the development of antiviral or anticancer agents, as they can improve the pharmacokinetic profile and reduce susceptibility to nucleases. The compound's structure suggests potential applications in molecular biology and medicinal chemistry, particularly in the design of nucleoside analogs for therapeutic use.

Formula: C₃₇H₃₄FN₃O₇

Synonyms:

• Cytidine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro-
• 5'-O-DMT-N4-Bz-2'-F-dC
• N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro- Cytidine

5'-O-DMT-N4-Bz-2'-F-dC

CAS: 146954-77-0

5'-O-DMT-N4-Bz-2'-F-dC

Purity: 98%

Molecular weight: 651.68g/mol

Ref: 54-PC110540

5'-O-DMT-N4-Bz-2'-F-dC

CAS: 146954-77-0

5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.

Formula: C₃₇H₃₄FN₃O₇

Color and Shape: Solid

Molecular weight: 651.68

Ref: TM-T37137

5'-O-DMT-N4-Bz-2'-F-dC

CAS: 146954-77-0

Molecular weight: 651.691

Ref: 10-F987427

N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluorocytidine

CAS: 146954-77-0

N4-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluorocytidine (BDF) is a novel phosphoramidate prodrug of cytosine that has been synthesized for use in antiviral therapy. It is a DNA chain terminator and inhibits viral replication by inhibiting the synthesis of viral DNA. BDF is activated to cytosine monophosphate (CMP) by phosphodiesterase enzymes and then converted to cytosine diphosphate (CDP), which inhibits DNA synthesis. The synthesis of viral RNA is also inhibited, leading to inhibition of protein synthesis and cell death.

Formula: C₃₇H₃₄FN₃O₇

Purity: Min. 95%

Color and Shape: White solid.

Molecular weight: 651.7 g/mol

Ref: 3D-NB08367