CAS 147025-53-4

Talsaclidine

Description:

Talsaclidine is a chemical compound that belongs to the class of muscarinic receptor antagonists, primarily investigated for its potential therapeutic applications in treating cognitive disorders, particularly Alzheimer's disease. It is characterized by its ability to selectively inhibit certain subtypes of muscarinic acetylcholine receptors, which play a crucial role in neurotransmission and cognitive function. The compound is known for its favorable pharmacokinetic properties, including good oral bioavailability and a manageable half-life, which contribute to its potential efficacy in clinical settings. Talsaclidine's chemical structure features specific functional groups that enhance its binding affinity to target receptors while minimizing off-target effects. Research has indicated that it may improve cognitive performance and memory retention in preclinical models, although further studies are necessary to fully understand its safety profile and therapeutic potential in humans. As with many investigational drugs, ongoing clinical trials will provide more insights into its effectiveness and possible side effects.

Formula: C₁₀H₁₅NO

InChI: InChI=1/C10H15NO/c1-2-7-12-10-8-11-5-3-9(10)4-6-11/h1,9-10H,3-8H2/t10-/m0/s1

InChI key: InChIKey=XVFJONKUSLSKSW-JTQLQIEISA-N

SMILES: O(CC#C)[C@@H]1[C@@]2(CCN(C1)CC2)[H]

Synonyms:

• (3R)-3-(2-Propyn-1-yloxy)-1-azabicyclo[2.2.2]octane
• (3R)-3-(prop-2-yn-1-yloxy)-1-azabicyclo[2.2.2]octane
• (R)-3-(2-Propynyloxy)-1-Azabicyclo[2.2.2]octane, WAL 2014
• (R)-3-(2-Propynyloxy)-1-azabicyclo[2.2.2]octane
• 1-Azabicyclo[2.2.2]octane, 3-(2-propyn-1-yloxy)-, (3R)-
• 1-Azabicyclo[2.2.2]octane, 3-(2-propynyloxy)-, (R)-
• Talsaclidine
• WAL 2014

1-Azabicyclo[2.2.2]octane, 3-(2-propyn-1-yloxy)-, (3R)-

CAS: 147025-53-4

Formula: C₁₀H₁₅NO

Purity: 97.0%

Color and Shape: Liquid

Molecular weight: 165.2322

Ref: IN-DA001EJJ

Talsaclidine

CAS: 147025-53-4

Formula: C₁₀H₁₅NO

Molecular weight: 165.23

Ref: 7W-GK0476

Talsaclidine

Controlled Product

CAS: 147025-53-4

Formula: C₁₀H₁₅NO

Color and Shape: Neat

Molecular weight: 165.23

Ref: TR-T005600

Talsaclidine Hydrochloride

Controlled Product

CAS: 147025-53-4

Applications Talsaclidine, a novel M1-receptor selective muscarinic agonist for cholinergic substitution therapy of Alzheimer's disease. Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease.
References Hock, et al.: Amyloid, 10(1), 1 (2003), Moreau, M., et al.: J. Pharmacol. Sci., 99, 6 (2005),

Formula: C₁₀H₁₆ClNO

Color and Shape: Neat

Molecular weight: 201.69

Ref: TR-T005601

Talsaclidine

CAS: 147025-53-4

Talsaclidine: full M1 agonist, partial M2/M3 agonist with neuron-stimulating effects.

Formula: C₁₀H₁₅NO

Purity: 98%

Color and Shape: Solid

Molecular weight: 165.23

Ref: TM-T13071