CAS 147059-72-1

TROVAFLOXACIN

Description:

Trovafloxacin is a synthetic fluoroquinolone antibiotic that exhibits broad-spectrum antibacterial activity. It is primarily used to treat various bacterial infections, particularly those caused by Gram-positive and Gram-negative organisms. The compound works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription, thereby preventing bacterial cell division and growth. Trovafloxacin is characterized by its relatively high potency against certain pathogens, including those resistant to other antibiotics. It is typically administered orally or intravenously and has a favorable pharmacokinetic profile, allowing for once-daily dosing in many cases. However, its use has been limited due to concerns about hepatotoxicity and the potential for serious side effects, leading to its withdrawal from the market in some regions. Additionally, like other fluoroquinolones, it may be associated with risks of tendon rupture and central nervous system effects. Overall, while Trovafloxacin demonstrates effective antibacterial properties, its safety profile necessitates careful consideration in clinical use.

Formula: C₂₀H₁₅F₃N₄O₃

InChI: InChI=1/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-6,24H2,(H,29,30)/t10-,11+,16+

InChI key: InChIKey=WVPSKSLAZQPAKQ-CDMJZVDBNA-N

SMILES: O=C1C=2C(N(C=C1C(O)=O)C3=C(F)C=C(F)C=C3)=NC(=C(F)C2)N4C[C@]5([C@@](C4)([C@@H]5N)[H])[H]

Synonyms:

• (1α,5α,6α)-7-(6-Amino-3-azabi-cyclo[3.1.0]hex-3-y1)-1-(2,4-difluomphenyl)-6-fluom-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 1,8-Naphthyridine-3-carboxylic acid, 7-(1.alpha.,5.alpha.,6.alpha.)-6-amino-3-azabicyclo3.1.0hex-3-yl-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-
• 1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-
• 3-Azabicyclo[3.1.0]hexane, 1,8-naphthyridine-3-carboxylic acid deriv.
• 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• Cp-99219
• Trovan：CP-99219-27
• Turvel
• Trovafloxacin
• 7-[(1R,5S)-6-azanyl-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
• 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-

CAS: 147059-72-1

Formula: C₂₀H₁₅F₃N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 416.3533

Ref: IN-DA001EKY

Trovafloxacin

CAS: 147059-72-1

Formula: C₂₀H₁₅F₃N₄O₃

Molecular weight: 416.35

Ref: 7W-GP2666

Trovafloxacin

CAS: 147059-72-1

Trovafloxacin, a broad-spectrum quinolone antibiotic, exhibits potent activity against Gram-positive bacteria.

Formula: C₂₀H₁₅F₃N₄O₃

Purity: 99.21% - 99.27%

Color and Shape: Solid

Molecular weight: 416.35

Ref: TM-T13231

Trovafloxacin

Controlled Product

CAS: 147059-72-1

Applications Trovafloxacin is a fluroquinolone antibiotic, recently identified as an inhibitor of pannexin-1 (Panx1) channels. Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice.
References Garg, C., et al.: J. Neuroinflammation, 15, 42 (2018); Angus, J. A., et al.: Eur. J. Pharmacol., 791, 179 (2016)

Formula: C₂₀H₁₅F₃N₄O₃

Color and Shape: Neat

Molecular weight: 402.37

Ref: TR-T892760

(1R,5R,6R)-7-(6-Amino-3-Azabicyclo[3.1.0]Hex-3- Yl)-1-(2,4-difluorophenyl)-6-Fluoro-1,4-dihydro-4-Oxo-1,8-naphthyridine-3-carbox

CAS: 147059-72-1

The mechanism of action of ciprofloxacin is to bind to the bacterial ribosome, thereby inhibiting protein synthesis. Ciprofloxacin is a broad-spectrum antibiotic that has been shown to be effective against both gram-positive and gram-negative bacteria, including methicillin resistant Staphylococcus aureus (MRSA). Ciprofloxacin is also active against Mycobacterium tuberculosis and Mycobacterium avium complex. It binds to the 30S ribosomal subunit, preventing attachment of aminoacyl tRNA. The addition of tetracycline can increase the activity of ciprofloxacin by inhibiting the efflux pump in the bacterial cell membrane. Ciprofloxacin has been found to have synergistic effects when used in combination with trovafloxacin or other antibiotics that act on different targets.

Formula: C₂₀H₁₅F₃N₄O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 416.35 g/mol

Ref: 3D-FA103840