CAS 147059-75-4

Trovafloxacin mesylate

Description:

Trovafloxacin mesylate is a synthetic fluoroquinolone antibiotic that exhibits broad-spectrum antibacterial activity. It is primarily used to treat various bacterial infections, particularly those caused by Gram-positive and Gram-negative organisms. The compound functions by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. Trovafloxacin mesylate is characterized by its high potency against a range of pathogens, including some strains resistant to other antibiotics. It is typically administered orally or intravenously, depending on the severity of the infection. The mesylate salt form enhances its solubility and stability, facilitating better absorption in the body. However, its use has been limited due to concerns about hepatotoxicity and the potential for serious side effects, leading to its withdrawal from the market in some regions. As with other fluoroquinolones, caution is advised in patients with a history of tendon disorders or those taking concurrent medications that may interact. Overall, Trovafloxacin mesylate represents a significant advancement in antibiotic therapy, albeit with important safety considerations.

Formula: C₂₀H₁₅F₃N₄O₃·CH₄O₃S

InChI: InChI=1/C20H15F3N4O3.CH4O3S/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24;1-5(2,3)4/h1-4,7,10-11,16H,5-6,24H2,(H,29,30);1H3,(H,2,3,4)/t10-,11+,16+;

InChI key: InChIKey=DYNZICQDCVYXFW-AHZSKCOENA-N

SMILES: O=C1C=2C(N(C=C1C(O)=O)C3=C(F)C=C(F)C=C3)=NC(=C(F)C2)N4C[C@]5([C@@](C4)([C@@H]5N)[H])[H].S(C)(=O)(=O)O

Synonyms:

• 1,8-Naphthyridine-3-carboxylic acid, 7-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, (1α,5α,6α)-, monomethanesulfonate
• 1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, methanesulfonate (1:1)
• 3-Azabicyclo[3.1.0]hexane, 1,8-naphthyridine-3-carboxylic acid deriv.
• 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate (1:1)
• Cp 99219
• Cp 99219-27
• Trovafloxacin Mesylate
• Trovafloxacin methanesulfonate
• Trovafloxacin monomethanesulfonate
• Trovan

Trovafloxacin (mesylate)

CAS: 147059-75-4

Formula: C₂₁H₁₉F₃N₄O₆S

Purity: 99%

Color and Shape: Solid

Molecular weight: 512.4590

Ref: IN-DA001EKX

Trovafloxacin mesylate

CAS: 147059-75-4

Formula: C₂₀H₁₅F₃N₄O₃·CH₃SO₃H

Molecular weight: 512.46

Ref: 7W-GP0738

Trovafloxacin mesylate

CAS: 147059-75-4

Trovafloxacin mesylate

Purity: ≥98%

Molecular weight: 512.46g/mol

Ref: 54-BUP04651

Trovafloxacin Mesylate

Controlled Product

CAS: 147059-75-4

Applications Fluorinated quinolone antibacterial. Trovafloxacin mesylate blocks the activity of DNA gyrase and topoisomerase IV, enzymes essential in the repliction, transcription, and repair of bacterial DNA.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Neu, H.C., et al.: Clin. Antimicrob. Agents Chemother., 38, 2615 (1994), Liguori, M.J., et al.: Hepatology, 41, 177 (2005),

Formula: C₂₀H₁₅F₃N₄O₃·CH₄O₃S

Color and Shape: Neat

Molecular weight: 512.46

Ref: TR-T893000

Trovafloxacin mesylate

CAS: 147059-75-4

Trovafloxacin mesylate is a synthetic antibiotic belonging to the fluoroquinolone class, which is derived from chemical synthesis processes rather than natural sources. The mode of action of trovafloxacin mesylate involves the inhibition of bacterial enzymes DNA gyrase and topoisomerase IV. These enzymes are essential for DNA replication, repair, and transcription within the bacterial cell. By inhibiting these enzymes, trovafloxacin mesylate disrupts bacterial DNA processes, leading to cell death and exerting its antibacterial effects.

Formula: C₂₁H₁₉F₃N₄O₆S

Purity: Min. 95%

Molecular weight: 512.46 g/mol

Ref: 3D-FT28618

Trovafloxacin mesylate

CAS: 147059-75-4

Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).

Formula: C₂₁H₁₉F₃N₄O₆S

Purity: 99.18%

Color and Shape: Solid

Molecular weight: 512.46

Ref: TM-T13231L