CAS 147059-75-4: Trovafloxacin mesylate

Description: Trovafloxacin mesylate is a synthetic fluoroquinolone antibiotic that exhibits broad-spectrum antibacterial activity. It is primarily used to treat various bacterial infections, particularly those caused by Gram-positive and Gram-negative organisms. The compound functions by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication and transcription. Trovafloxacin mesylate is characterized by its high potency against a range of pathogens, including some strains resistant to other antibiotics. It is typically administered orally or intravenously, depending on the severity of the infection. The mesylate salt form enhances its solubility and stability, facilitating better absorption in the body. However, its use has been limited due to concerns about hepatotoxicity and the potential for serious side effects, leading to its withdrawal from the market in some regions. As with other fluoroquinolones, caution is advised in patients with a history of tendon disorders or those taking concurrent medications that may interact. Overall, Trovafloxacin mesylate represents a significant advancement in antibiotic therapy, albeit with important safety considerations.

Formula: C₂₀H₁₅F₃N₄O₃·CH₄O₃S

InChI: InChI=1/C20H15F3N4O3.CH4O3S/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24;1-5(2,3)4/h1-4,7,10-11,16H,5-6,24H2,(H,29,30);1H3,(H,2,3,4)/t10-,11+,16+;

InChI key: InChIKey=DYNZICQDCVYXFW-AHZSKCOENA-N

SMILES: O=C(O)C1=CN(C2=NC(=C(F)C=C2C1=O)N3CC4C(N)C4C3)C5=CC=C(F)C=C5F.O=S(=O)(O)C

Synonyms:

• 1,8-Naphthyridine-3-carboxylic acid, 7-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, (1α,5α,6α)-, monomethanesulfonate
• 1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, methanesulfonate (1:1)
• 3-Azabicyclo[3.1.0]hexane, 1,8-naphthyridine-3-carboxylic acid deriv.
• 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate (1:1)
• Cp 99219
• Cp 99219-27
• Trovafloxacin Mesylate
• Trovafloxacin methanesulfonate
• Trovafloxacin monomethanesulfonate
• Trovan

1,8-Naphthyridine-3-carboxylic acid, 7-[(1α,5α,6α)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, methanesulfonate (1:1)

CAS: 147059-75-4

• Formula: C₂₀H₁₅F₃N₄O₃
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 416.3533

Trovafloxacin mesylate

CAS: 147059-75-4

• Formula: C₂₀H₁₅F₃N₄O₃·CH₃SO₃H
• Molecular weight: 512.46

Trovafloxacin mesylate

CAS: 147059-75-4

• Purity: 99.11%
• Molecular weight: 512.46g/mol

Trovafloxacin Mesylate

CAS: 147059-75-4

Applications Fluorinated quinolone antibacterial. Trovafloxacin mesylate blocks the activity of DNA gyrase and topoisomerase IV, …

• Formula: C₂₀H₁₅F₃N₄O₃·CH₄O₃S
• Color and Shape: Neat
• Molecular weight: 512.46

Trovafloxacin mesylate

CAS: 147059-75-4

Please enquire for more information about Trovafloxacin mesylate including the price, delivery time and more …

• Formula: C₂₁H₁₉F₃N₄O₆S
• Purity: Min. 95%
• Molecular weight: 512.46 g/mol

Trovafloxacin mesylate

CAS: 147059-75-4

Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).

• Formula: C₂₁H₁₉F₃N₄O₆S
• Purity: 99.12%
• Color and Shape: Solid
• Molecular weight: 512.46