CAS 147076-36-6

Laflunimus

Description:

Laflunimus, with the CAS number 147076-36-6, is a chemical compound that belongs to the class of immunosuppressants. It is primarily recognized for its role in the treatment of autoimmune diseases, particularly rheumatoid arthritis. The substance functions by inhibiting the activity of certain enzymes involved in the immune response, thereby reducing inflammation and modulating the immune system. Laflunimus is typically administered orally and is known for its relatively favorable safety profile compared to other immunosuppressive agents. Common side effects may include gastrointestinal disturbances and potential impacts on liver function, necessitating regular monitoring. Its mechanism of action involves the inhibition of lymphocyte proliferation, which is crucial in managing conditions characterized by excessive immune activity. As with any medication, the use of Laflunimus should be guided by a healthcare professional, considering the individual patient's health status and potential drug interactions. Overall, Laflunimus represents a valuable option in the therapeutic arsenal for managing chronic inflammatory conditions.

Formula: C₁₅H₁₃F₃N₂O₂

InChI: InChI=1/C15H13F3N2O2/c1-8-6-10(4-5-12(8)15(16,17)18)20-14(22)11(7-19)13(21)9-2-3-9/h4-6,9,20,22H,2-3H2,1H3/b14-11-

SMILES: Cc1cc(ccc1C(F)(F)F)N/C(=C(\C#N)/C(=O)C1CC1)/O

Synonyms:

• Laflunimus [INN]
• (Z)alpha-Cyano-alpha(sup 4'),alpha(sup 4'),alpha(sup 4')-trifluoro-beta-hydroxycyclopropaneacrylo-3',4'-xylide
• Unii-44Eh625Ius
• (2Z)-2-(cyclopropylcarbonyl)-3-hydroxy-3-{[3-methyl-4-(trifluoromethyl)phenyl]amino}prop-2-enenitrile

Laflunimus Sodium Salt

Controlled Product

CAS: 147076-36-6

Applications Laflunimus Sodium Salt, is used to treat neuropathic pain and the neuropathic pain syndromes.
References Hasse, B., et al.: PCT Int. Appl. (2012), WO 2012055567 A2 20120503

Formula: C₁₅H₁₂F₃N₂NaO₂

Color and Shape: Neat

Molecular weight: 332.25

Ref: TR-L168510

Laflunimus Sodium Salt-d4

Controlled Product

CAS: 147076-36-6

Formula: C₁₅D₄H₈F₃N₂NaO₂

Color and Shape: Neat

Molecular weight: 336.278

Ref: TR-L168512

Laflunimus

CAS: 147076-36-6

Laflunimus (HR325) is a DHODH inhibitor that inhibits immunoglobulin secretion in vitro and in vivo,by interfering with pyrimidine metabolism,neuralgia.

Formula: C₁₅H₁₃F₃N₂O₂

Purity: 99.86%

Color and Shape: Solid

Molecular weight: 310.27

Ref: TM-T11813