CAS 147081-49-0

(R)-tert-Butyl 3-aminopyrrolidine-1-carboxylate

Description:

(R)-tert-Butyl 3-aminopyrrolidine-1-carboxylate is a chiral compound characterized by its pyrrolidine ring structure, which is a five-membered nitrogen-containing heterocycle. The presence of the tert-butyl group enhances its lipophilicity, making it more soluble in organic solvents. This compound features an amino group and a carboxylate functional group, which contribute to its potential as a building block in organic synthesis and pharmaceutical applications. The chirality of the molecule, indicated by the (R) configuration, is significant in determining its biological activity and interactions with other chiral molecules. The CAS number 147081-49-0 uniquely identifies this substance in chemical databases, facilitating its study and application in various fields, including medicinal chemistry and drug development. Its structural characteristics suggest potential uses in the synthesis of more complex molecules, particularly in the development of pharmaceuticals targeting specific biological pathways. Overall, (R)-tert-Butyl 3-aminopyrrolidine-1-carboxylate is a versatile compound with important implications in chemical research and application.

Formula: C₉H₁₈N₂O₂

InChI: InChI=1/C9H18N2O2.ClH/c1-9(2,3)13-8(12)11-5-4-7(10)6-11;/h7H,4-6,10H2,1-3H3;1H/t7-;/m1./s1

InChI key: InChIKey=CMIBWIAICVBURI-SSDOTTSWSA-N

SMILES: C(OC(C)(C)C)(=O)N1CC[C@@H](N)C1

Synonyms:

• (+)-3-Aminopyrrolidine-1-carboxylic acid (R)-tert-butyl ester
• (3R)-(+)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine
• (3R)-3-Aminopyrrolidine-1-carboxylic acid tert-butyl ester
• (R)-(+)-3-Amino-1-(tert-butoxycarbonyl)pyrrolidine
• (R)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine
• (R)-1-Boc-3-aminopyrrolidine
• (R)-1-N-Boc-3-Aminopyrrolidine
• (R)-3-Amino-1-Boc-pyrrolidine
• (R)-3-Amino-1-tert-butoxycarbonylpyrrolidine
• (R)-3-Amino-N-(tert-butoxycarbonyl)pyrrolidine
• (R)-3-Aminopyrrolidine-1-carboxylic acid tert-butyl ester
• (R)-N-tert-Butoxycarbonyl-3-aminopyrrolidine
• (R)-tert-Butyl 3-aminopyrrolidine-1-carboxylate
• 1,1-Dimethylethyl (3R)-3-amino-1-pyrrolidinecarboxylate
• 1,1-dimethylethyl (3R)-3-aminopyrrolidine-1-carboxylate
• 1-Boc-(R)-3-aminopyrrolidine
• 1-Boc-3-(R)-aminopyrrolidine
• 1-N-Boc-3-(R)-aminopyrrolidine
• 1-Pyrrolidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester, (3R)-
• 1-Pyrrolidinecarboxylic acid, 3-amino-, 1,1-dimethylethyl ester, (R)-
• 1-t-butoxycarbonyl-3-R-aminopyrrolidine
• N-Boc-(3R)-aminopyrrolidine
• R-1-N-Boc-3-Amino Pyrrolidine
• R-N-boc-3-Amino Pyrrolidine
• tert-Butyl (R)-3-amino-1-pyrrolidinecarboxylate
• tert-Butyl (R)-3-aminopyrrolidine-1-carboxylate
• tert-butyl (3R)-3-aminopyrrolidine-1-carboxylate
• (R)-N-Boc-3-aminopyrrolidine
• (R)-3-AMINO-1-N-(T-BUTOXYCARBONYL)PYRROLIDINE
• (R)-3-AMINO-1-N-BOC-PYRROLIDINE, CITRIC ACID SALT
• (R)-3-AMINO-1-N-(TERT-BUTOXYCARBONYL)PYRROLIDINE
• (R)-3-AMINO-N-BOC-PYRROLIDINE
• (R)-(+)-1-TBOC-3-AMINOPYRROLIDINE
• (3R)-3-Amino-1-(tert-butoxycarbonyl)pyrrolidine
• 3-AMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, (R)
• (R)-3-AMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(3R)-(+)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine

CAS: 147081-49-0

Formula: C₉H₁₈N₂O₂

Purity: >98.0%(GC)(T)

Color and Shape: Colorless to Light orange to Yellow clear liquid

Molecular weight: 186.26

Ref: 3B-B2920

(R)-(+)-1-Boc-3-aminopyrrolidine, 97%

CAS: 147081-49-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₉H₁₈N₂O₂

Purity: 97%

Color and Shape: Clear colorless to pale yellow, Liquid

Molecular weight: 186.26

Ref: 02-H28188

(3R)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine

CAS: 147081-49-0

Formula: C₉H₁₈N₂O₂

Purity: 95%

Color and Shape: Liquid

Molecular weight: 186.2514

Ref: IN-DA0032DY

(3R)-3-Aminopyrrolidine, N1-BOC protected

CAS: 147081-49-0

(3R)-3-Aminopyrrolidine, N1-BOC protected

Formula: C₉H₁₈N₂O₂

Purity: 95%

Color and Shape: colourless liquid

Molecular weight: 186.25g/mol

Ref: 54-OR4635

(R)-3-Amino-1-N-Boc-pyrrolidine

CAS: 147081-49-0

Formula: C₉H₁₈N₂O₂

Purity: 98.0%

Color and Shape: Liquid, Oil

Molecular weight: 186.255

Ref: 10-F011315

(R)-1-Boc-3-Aminopyrrolidine

CAS: 147081-49-0

(R)-1-Boc-3-Aminopyrrolidine is a small molecule that inhibits 3-kinase. It has been shown to bind to the ATP binding site of PI3Kδ and inhibit its activity. This results in the inhibition of phosphoinositide production, which leads to decreased cell proliferation and survival. (R)-1-Boc-3-Aminopyrrolidine has also been shown to have selectivity for isoform α over β, γ, and δ. The drug binds specifically to the ATP binding site on PI3Kδ, but does not disrupt other interactions such as hydrogen bonding or pi stacking interactions with residues in the vicinity of the ATP binding site. The IC50 values for (R)-1-Boc-3-Aminopyrrolidine were determined using siRNA knockdown experiments against human isoform α PI3Kδ.

Formula: C₉H₁₈N₂O₂

Purity: Min. 95%

Molecular weight: 186.25 g/mol

Ref: 3D-FB41617