CAS 147098-18-8

Rosuvastatin sodium

Description:

Rosuvastatin sodium is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular disease. Its mechanism of action involves the inhibition of HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis in the liver, leading to decreased levels of low-density lipoprotein (LDL) cholesterol and triglycerides while increasing high-density lipoprotein (HDL) cholesterol. The substance is characterized by its high potency and long half-life, allowing for once-daily dosing. Rosuvastatin sodium is typically administered in tablet form and is well-absorbed in the gastrointestinal tract. It exhibits good solubility in water, which contributes to its bioavailability. Common side effects may include muscle pain, gastrointestinal disturbances, and, in rare cases, liver enzyme elevations. Due to its efficacy and safety profile, Rosuvastatin sodium is widely prescribed and has been the subject of extensive clinical research to evaluate its long-term benefits and risks in various populations.

Formula: C₂₂H₂₇FN₃NaO₆S

InChI: InChI=1/C22H28FN3O6S.Na/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32;/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30);/q;+1/p-1/b10-9+;

SMILES: CC(C)c1c(C=CC(CC(CC(=O)O)O)O)c(c2ccc(cc2)F)nc(n1)N(C)S(=O)(=O)C.[Na]

Synonyms:

• 7-{4-(4-Fluorophenyl)-6-Isopropyl-2-[Methyl(Methylsulfonyl)Amino]Pyrimidin-5-Yl}-3,5-Dihydroxyhept-6-Enoic Acid
• Crestor
• Rosuvastatin Ca
• Rosuvastatin, Calcium Salt
• 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-(N-methyl-N-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid sodium salt
• calcium bis[(3R,5S,6E)-7-{4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoate]
• calcium bis{(6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate}

6-Heptenoic acid,7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, monosodium salt, (3R,5S,6E)-

CAS: 147098-18-8

Formula: C₂₂H₂₇FN₃NaO₆S

Purity: 97%

Color and Shape: Solid

Molecular weight: 503.5195

Ref: IN-DA00HXJY

Rosuvastatin sodium salt

CAS: 147098-18-8

Formula: C₂₂H₂₇FN₃O₆S·Na

Purity: ≥ 97.0%

Color and Shape: White to off-white or beige powder or crystals

Molecular weight: 503.52

Ref: 7W-GP9530

Rosuvastatin Sodium Salt

CAS: 147098-18-8

Formula: C₂₂H₂₇FN₃O₆S·Na

Color and Shape: White To Off-White Solid

Molecular weight: 480.53 22.99

Ref: 4Z-R-0938

Rosuvastatin Sodium

CAS: 147098-18-8

Rosuvastatin Sodium

Purity: 97%

Molecular weight: 503.52g/mol

Ref: 54-PC108549

Rosuvastatin Sodium

CAS: 147098-18-8

Rosuvastatin Sodium: HMGCR inhibitor, blocks hERG (IC50: 11 nM, 195 nM), reduces hERG expression, hinders Hsp70-hERG interaction.

Formula: C₂₂H₂₇FN₃NaO₆S

Color and Shape: Solid

Molecular weight: 503.52

Ref: TM-T63430

Rosuvastatin-d6 Sodium Salt

Controlled Product

CAS: 147098-18-8

Formula: C₂₂H₂₁D₆FN₃NaO₆S

Color and Shape: Neat

Molecular weight: 509.56

Ref: TR-R700502

Rosuvastatin sodium

CAS: 147098-18-8

Rosuvastatin sodium salt is a statin drug that inhibits the enzyme HMG-CoA reductase. It is used to lower cholesterol and triglyceride levels in the blood, and to prevent heart attacks and strokes. Rosuvastatin sodium salt has been shown to have anti-inflammatory activity in human liver cells, which may be due to its ability to suppress the release of proinflammatory cytokines. Rosuvastatin sodium salt has also been shown to have synergistic effects with other drugs such as desipramine hydrochloride in primary cells, which may be due to its ability to inhibit the activity of cytochrome P450 enzymes. This drug is metabolized by alkali hydrolysis into rosuvastatin acid, which is then converted into an active form by polymorphic esterases in the liver. The active form can then be hydrolyzed by plasma esterases into inactive metabolites.
Rosuvastatin sodium salt is a crystalline powder

Formula: C₂₂H₂₈FN₃O₆S•Na

Purity: Min. 96 Area-%

Color and Shape: White Powder

Molecular weight: 504.53 g/mol

Ref: 3D-FR33470

Rosuvastatin Sodium Salt

Controlled Product

CAS: 147098-18-8

Applications Rosuvastatin sodium salt (CAS# 147098-18-8) is a useful research chemical compound.

Formula: C₂₂H₂₇FN₃O₆S·Na

Color and Shape: Neat

Molecular weight: 503.52

Ref: TR-R225340

Rosuvastatin Sodium Salt

CAS: 147098-18-8

Formula: C₂₂H₂₇FN₃O₆SNa

Molecular weight: 480.53 : 23.0

Ref: ST-EA-CP-R1153