CAS 147116-64-1

Ezlopitant

Description:

Ezlopitant, identified by the CAS number 147116-64-1, is a chemical compound that functions primarily as a selective antagonist of the neurokinin-1 (NK1) receptor. This receptor is involved in various physiological processes, including pain perception and the regulation of mood. Ezlopitant has garnered attention for its potential therapeutic applications, particularly in the treatment of chronic pain conditions and anxiety disorders. The compound exhibits a favorable pharmacokinetic profile, which includes good oral bioavailability and a manageable half-life, making it suitable for clinical use. In terms of its chemical structure, Ezlopitant features specific functional groups that contribute to its receptor-binding affinity and selectivity. Additionally, it has undergone various preclinical and clinical studies to assess its efficacy and safety, showing promise in alleviating symptoms associated with conditions like migraine and other pain syndromes. As research continues, Ezlopitant may offer new avenues for pain management and improve the quality of life for patients suffering from chronic pain.

Formula: C₃₁H₃₈N₂O

InChI: InChI=1S/C31H38N2O/c1-22(2)26-14-15-28(34-3)27(20-26)21-32-30-25-16-18-33(19-17-25)31(30)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24/h4-15,20,22,25,29-32H,16-19,21H2,1-3H3/t30-,31-/m0/s1

InChI key: InChIKey=XPNMCDYOYIKVGB-CONSDPRKSA-N

SMILES: C([C@H]1[C@@H](NCC2=C(OC)C=CC(C(C)C)=C2)C3CCN1CC3)(C4=CC=CC=C4)C5=CC=CC=C5

Synonyms:

• (2S,3S)-2-(Diphenylmethyl)-N-(5-isopropyl-2-methoxybenzyl)quinuclidin-3-amine
• (2S,3S)-2-(Diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl]-1-azabicyclo[2.2.2]octan-3-amine
• 1-Azabicyclo[2.2.2]octan-3-amine, 2-(diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl]-, (2S,3S)-
• 1-Azabicyclo[2.2.2]octan-3-amine, 2-(diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl]-, (2S-cis)-
• Cj 11974
• Ezlopitant

Ezlopitant

CAS: 147116-64-1

Ezlopitant (CJ-11974) is a small molecule neurokinin-1-receptor (NK1) antagonist used to treat nausea, vomiting and pain.

Formula: C₃₁H₃₈N₂O

Purity: 97.49%

Color and Shape: Solid

Molecular weight: 454.65

Ref: TM-T68068

Ezlopitant

CAS: 147116-64-1

Ezlopitant

Purity: ≥95%

Molecular weight: 454.65g/mol

Ref: 54-BUP08101

Ezlopitant

CAS: 147116-64-1

Formula: C₃₁H₃₈N₂O

Molecular weight: 454.66

Ref: 4Z-E-206001