CAS 147116-67-4

Maropitant

Description:

Maropitant is a synthetic antiemetic agent primarily used in veterinary medicine to prevent and treat vomiting in dogs and cats. It functions as a neurokinin-1 (NK1) receptor antagonist, effectively blocking the action of substance P, a neuropeptide involved in the vomiting reflex. Maropitant is characterized by its high oral bioavailability and rapid onset of action, making it suitable for both acute and chronic use. The substance is typically administered as an injectable solution or oral tablet, and it is well-tolerated in animals, with a low incidence of adverse effects. Its pharmacokinetics indicate a relatively long half-life, allowing for once-daily dosing in many cases. Maropitant is also noted for its ability to mitigate nausea associated with various conditions, including motion sickness and chemotherapy. Overall, its efficacy and safety profile have made it a valuable tool in veterinary practice for managing emesis in companion animals.

Formula: C₃₂H₄₀N₂O

InChI: InChI=1S/C32H40N2O/c1-32(2,3)27-15-16-28(35-4)26(21-27)22-33-30-25-17-19-34(20-18-25)31(30)29(23-11-7-5-8-12-23)24-13-9-6-10-14-24/h5-16,21,25,29-31,33H,17-20,22H2,1-4H3/t30-,31-/m0/s1

InChI key: InChIKey=OMPCVMLFFSQFIX-CONSDPRKSA-N

SMILES: C([C@H]1[C@@H](NCC2=C(OC)C=CC(C(C)(C)C)=C2)C3CCN1CC3)(C4=CC=CC=C4)C5=CC=CC=C5

Synonyms:

• (2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine
• (2S,3S)-N-[[5-(1,1-Dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine
• 1-Azabicyclo[2.2.2]octan-3-amine, N-[[5-(1,1-dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-, (2S,3S)-
• 1-Azabicyclo[2.2.2]octan-3-amine, N-[[5-(1,1-dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-, (2S-cis)-
• Maropitant
• Prevomax
• Maropitant Citrate

1-Azabicyclo[2.2.2]octan-3-amine, N-[[5-(1,1-dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-, (2S,3S)-

CAS: 147116-67-4

Formula: C₃₂H₄₀N₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 468.6728

Ref: IN-DA001ELW

Maropitant

CAS: 147116-67-4

Maropitant

Purity: ≥95%

Molecular weight: 468.67g/mol

Ref: 54-BUP15464

Maropitant-13C-d3

CAS: 147116-67-4

Formula: C₃₁₁₃CH₃₇D₃N₂O

Color and Shape: White To Off-White Solid

Molecular weight: 472.70

Ref: 4Z-M-169002

Maropitant

CAS: 147116-67-4

Formula: C₃₂H₄₀N₂O

Molecular weight: 468.69

Ref: 4Z-M-169018

Maropitant

CAS: 147116-67-4

Maropitant is a selective neurokinin (NK1) receptor antagonist.

Formula: C₃₂H₄₀N₂O

Purity: 97.35% - 99.75%

Color and Shape: Solid

Molecular weight: 468.67

Ref: TM-T7209

Maropitant-d3

Controlled Product

CAS: 147116-67-4

Formula: C₃₂D₃H₃₇N₂O

Color and Shape: Neat

Molecular weight: 471.691

Ref: TR-M197302