CAS 147118-36-3

N-[4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide

Description:

N-[4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide, with CAS number 147118-36-3, is a chemical compound that belongs to the class of sulfonamides. This substance features a pyrimidine ring substituted with various functional groups, including a fluorophenyl moiety and a hydroxymethyl group, which contribute to its biological activity. The presence of the methanesulfonamide group indicates potential applications in medicinal chemistry, particularly in the development of pharmaceuticals. The compound's structure suggests it may exhibit properties such as enzyme inhibition or modulation of biological pathways, making it of interest in drug discovery. Additionally, the fluorine atom can enhance lipophilicity and metabolic stability, which are desirable traits in drug design. Overall, this compound's unique structural features and functional groups position it as a candidate for further investigation in therapeutic applications, particularly in areas related to oncology or infectious diseases.

Formula: C₁₆H₂₀FN₃O₃S

InChI: InChI=1S/C16H20FN3O3S/c1-10(2)14-13(9-21)15(11-5-7-12(17)8-6-11)19-16(18-14)20(3)24(4,22)23/h5-8,10,21H,9H2,1-4H3

InChI key: InChIKey=MSDYDUNHTAYBHV-UHFFFAOYSA-N

SMILES: C(O)C=1C(=NC(N(S(C)(=O)=O)C)=NC1C(C)C)C2=CC=C(F)C=C2

Synonyms:

• (Methanol) 4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulfonylamino)Pyrimidine-5-yl-Methanol
• 4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Mehyl-N-Mehylsulfonylamino)Pyrimidine-5-yl-Methanol
• 4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methanesulfonylamino) Pyrimidin-5-Methanol
• 4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulfonylamino)Pyrimidine-5-Me
• 4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulfonylamino)Pyrimidine-5-Methanol
• 4-(4-Fluorophenyl)-6-Isopropyl-2-[(N-Methyl-N-Methylsulfonyl)Amino]Pyrimidin-5-Yl-Methanol
• 4-(4-Fluorophenyl)-6-isopropyl-2- [(N-methyl-N- methylsulfony)amino]pyrimidine-5-yl-methanol
• 4-(4-Fluorophenyl)-6-isopropyl-2-[(n-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methonol
• 4-(4-Fluorophenyl)-6-isopropyl-2-[N(N-methylsuophonyl)amino]pyrimidine-5-yl-methanol
• 5-(Hydroxymethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine
• 6-(E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-methylsulfonyl-methyl pyrimidine-5-yl)vinyl)(4R,6S)-2,2-dimethyl)(1,3)-dioxane
• Methanesulfonamide, N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-
• Methyl 4-(4-Fluorophenyl)6-Isopropyl-2-(N-Methyl-N-Methylsulfonyl)Amino] Pyrimidine-5-Carbixylate
• N-[4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide
• N-[4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
• N-[4-(4-Fluorophenyl)-6-isopropyl-5-(hydroxymethyl)pyrimidin-2-yl]-N-methylmethanesulfonamide
• N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
• Rosuvastatin calcium intermediate R-1-2
• Z-7
• Z7
• Zd-2
• Methyl 4-(4-Fluorophenyl)6-Isopropyl-2-(N-Methyl-N-Methylsulfonyl)Amino] Pyrimidine-5-Carbixylate(Z-7)
• 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n- methylsulfonyl)amino]pyrimidine-5-yl-methanol
• 4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino] pyrimidine-5-yl-methanol

Methanesulfonamide, N-[4-(4-fluorophenyl)-5-(hydroxymethyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-

CAS: 147118-36-3

Formula: C₁₆H₂₀FN₃O₃S

Purity: 97%

Color and Shape: Solid

Molecular weight: 353.4117

Ref: IN-DA001EN2

4-(4-Fluorophenyl)-6-Isopropyl-2-[(N-Methyl-n-Methylsulfonyl)Amino]Pyrimidine-5-yl-Methanol

CAS: 147118-36-3

4-(4-Fluorophenyl)-6-Isopropyl-2-[(N-Methyl-n-Methylsulfonyl)Amino]Pyrimidine-5-yl-Methanol

Purity: 98%

Molecular weight: 353.41g/mol

Ref: 54-PC105229

Rosuvastatin Impurity 40

CAS: 147118-36-3

Formula: C₁₆H₂₀FN₃O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 353.41

Ref: 4Z-R-0944

4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine-5-methanol

Controlled Product

CAS: 147118-36-3

Formula: C₁₆H₂₀FN₃O₃S

Color and Shape: Neat

Molecular weight: 353.41

Ref: 86-MM0936.02

N-[4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

Controlled Product

CAS: 147118-36-3

Applications A Rosuvastatin (R700500) intermediate as HMG-CoA reductase inhibitor.
References Beck, et al.: J. Med. Chem., 33, 52 (1999),

Formula: C₁₆H₂₀FN₃O₃S

Color and Shape: Neat

Molecular weight: 353.41

Ref: TR-F595380

4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsufonyl)amino]pyrimidine-5-yl-methanol

CAS: 147118-36-3

Formula: C₁₆H₂₀FN₃O₃S

Purity: 97%

Color and Shape: Solid

Molecular weight: 353.41

Ref: 10-F093168

N-[4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide-d6

Controlled Product

CAS: 147118-36-3

Applications N-[4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide-d6 is an isotope labelled Rosuvastatin (R700500) intermediate as HMG-CoA reductase inhibitor.
References Beck, et al.: J. Med. Chem., 33, 52 (1999),

Formula: C₁₆H₁₄D₆FN₃O₃S

Color and Shape: Neat

Molecular weight: 359.45

Ref: TR-F595382

N-(4-(4-Fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-Nmethylmethanesulfonamide

CAS: 147118-36-3

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Formula: C₁₆H₂₀FN₃O₃S

Purity: Min. 95%

Molecular weight: 353.41 g/mol

Ref: 3D-FF57578

Rosuvastatin Hydroxymethyl Impurity

CAS: 147118-36-3

Formula: C₁₆H₂₀FN₃O₃S

Molecular weight: 353.41

Ref: ST-EA-CP-R1054