CAS 147118-39-6

Methyl (3R,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoate

Description:

Methyl (3R,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoate, with CAS number 147118-39-6, is a complex organic compound characterized by its specific stereochemistry and functional groups. This substance features a pyrimidine ring, which is a six-membered aromatic heterocycle containing nitrogen atoms, contributing to its biological activity. The presence of a fluorophenyl group enhances its lipophilicity and potential interactions with biological targets. The methylsulfonylamino group suggests possible applications in medicinal chemistry, particularly in drug design, due to its ability to modulate biological pathways. The heptenoate moiety indicates that it has unsaturation, which may influence its reactivity and stability. Overall, this compound's unique structure may confer specific pharmacological properties, making it of interest in the development of therapeutic agents. However, detailed studies would be necessary to fully elucidate its biological activity and potential applications.

Formula: C₂₃H₂₈FN₃O₆S

InChI: InChI=1S/C23H28FN3O6S/c1-14(2)21-19(11-10-17(28)12-18(29)13-20(30)33-4)22(15-6-8-16(24)9-7-15)26-23(25-21)27(3)34(5,31)32/h6-11,14,18,29H,12-13H2,1-5H3/b11-10+/t18-/m1/s1

InChI key: InChIKey=ULUNETUXUVEFLH-DOJUMQAQSA-N

SMILES: C(=C/C(C[C@H](CC(OC)=O)O)=O)\C=1C(=NC(N(S(C)(=O)=O)C)=NC1C(C)C)C2=CC=C(F)C=C2

Synonyms:

• (3R,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoic acid methyl ester
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-, methyl ester, (3R,6E)-
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-, methyl ester, [R-(E)]-
• H-2
• Methyl (3R,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoate
• Methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate
• Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate
• Methyl-(+)-(3R)-7-[4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-Methansul phonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate
• Methyl-(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-(methansulphonyl amino)pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate
• methyl (3R,6E)-7-{4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-5-oxohept-6-enoate

Methyl (+)-(3r)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(n-methyl-n-methanesulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6e)-heptenoate

CAS: 147118-39-6

Formula: C₂₃H₂₈FN₃O₆S

Purity: 98%

Color and Shape: Solid

Molecular weight: 493.5483

Ref: IN-DA001EMZ

5-Oxorosuvastatin methyl ester

CAS: 147118-39-6

5-Oxorosuvastatin methyl ester

Purity: 98%

Molecular weight: 493.56g/mol

Ref: 54-PC1007820

5-Oxorosuvastatin Methyl Ester

Controlled Product

CAS: 147118-39-6

Formula: C₂₃H₂₈FN₃O₆S

Color and Shape: Neat

Molecular weight: 493.55

Ref: 86-MM0936.03

5-Oxorosuvastatin Methyl Ester

CAS: 147118-39-6

Applications 5-Oxorosuvastatin methyl ester is an intermediate in the synthesis of Rosuvasatatin (calcium salt: R700500), a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that decreases high-sensitivity C-reactive protein (hsCRP) and cholesterol concentrations in the blood.
References McTaggart, F., et al.: Am. J. Cardiol., 87, 28 (2001); Ridker, P., et al.: Lancet, 373, 1175 (2009)

Formula: C₂₃H₂₈FN₃O₆S

Color and Shape: Yellow Solid

Molecular weight: 493.55

Ref: TR-O862005

Rosuvastatin 5-Oxo Acid Methyl Ester

CAS: 147118-39-6

Formula: C₂₃H₂₈FN₃O₆S

Molecular weight: 493.55

Ref: ST-EA-CP-R1048