CAS 147149-76-6

Nolatrexed

Description:

Nolatrexed is a synthetic compound primarily recognized for its role as an antitumor agent, particularly in the treatment of various cancers. It functions as a folate antagonist, inhibiting the enzyme dihydrofolate reductase, which is crucial for DNA synthesis and cell proliferation. This mechanism disrupts the folate metabolism in cancer cells, leading to their growth inhibition. Nolatrexed is characterized by its chemical structure, which includes a pyrimidine ring and a side chain that contributes to its biological activity. The compound is typically administered in a clinical setting and has been studied for its efficacy and safety profile in combination with other chemotherapeutic agents. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are essential for determining optimal dosing regimens. As with many chemotherapeutic agents, potential side effects may include myelosuppression, gastrointestinal disturbances, and other systemic effects, necessitating careful monitoring during treatment. Overall, Nolatrexed represents a significant advancement in targeted cancer therapy, contributing to the ongoing efforts to improve patient outcomes in oncology.

Formula: C₁₄H₁₂N₄OS

InChI: InChI=1S/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19)

InChI key: InChIKey=XHWRWCSCBDLOLM-UHFFFAOYSA-N

SMILES: S(C1=C2C(=CC=C1C)NC(N)=NC2=O)C=3C=CN=CC3

Synonyms:

• 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone
• 2-Amino-6-methyl-5-(4-pyridylthio)-4(3H)-quinazolinone
• 2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quinazolin-4-one
• 2-Amino-6-methyl-5-pyridin-4-ylsulfanyl-1H-quinazolin-4-one
• 2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)quinazolin-4(1H)-one
• 2-amino-6-methyl-5-(pyridin-4-ylsulfanyl)quinazolin-4(1H)-one dihydrochloride
• 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-
• Nolatrexed

4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-

CAS: 147149-76-6

Formula: C₁₄H₁₂N₄OS

Purity: 95%

Color and Shape: Solid

Molecular weight: 284.3363

Ref: IN-DA001EOA

Nolatrexed

CAS: 147149-76-6

Formula: C₁₄H₁₂N₄OS

Molecular weight: 284.34

Ref: 7W-GP3007

Nolatrexed

CAS: 147149-76-6

Nolatrexed

Purity: ≥95%

Molecular weight: 284.34g/mol

Ref: 54-BUP05154

Nolatrexed

CAS: 147149-76-6

Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.

Formula: C₁₄H₁₂N₄OS

Purity: 97.53%

Color and Shape: Solid

Molecular weight: 284.34

Ref: TM-T4228

Nolatrexed

CAS: 147149-76-6

Nolatrexed is an ion channel ligand that blocks voltage-gated sodium channels. It is a research tool for studying the function of ion channels, and is used in pharmacology to study protein interactions. Nolatrexed has also been shown to inhibit the growth of certain cancer cells by blocking the receptor for epidermal growth factor (EGF) and by inhibiting cell proliferation. Nolatrexed is also used as a research tool to study protein interactions in studies on Cell Biology and Pharmacology. The product is available as a high-purity powder at a purity of 98% or greater.

Formula: C₁₄H₁₂N₄OS

Purity: Min. 95%

Molecular weight: 284.34 g/mol

Ref: 3D-XFA14976