CAS 147201-04-5

5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Description:

The chemical substance known as "5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite" is a phosphoramidite derivative of guanosine, commonly used in the field of nucleic acid synthesis, particularly for the solid-phase synthesis of oligonucleotides. This compound features several key functional groups, including a dimethoxytrityl protecting group at the 5' position, which aids in the selective coupling of nucleotides during synthesis. The presence of a tert-butyl dimethylsilyl group at the 2' position provides additional protection against unwanted reactions, enhancing the stability of the nucleoside during the synthesis process. The isobutyryl group contributes to the overall stability and reactivity of the molecule, while the cyanoethyl phosphoramidite moiety is crucial for the formation of phosphodiester bonds in oligonucleotide synthesis. Overall, this compound is characterized by its complex structure, which facilitates the efficient and controlled assembly of nucleic acid sequences in laboratory settings.

Formula: C₅₀H₆₈N₇O₉PSi

Synonyms:

• 2'-TBDMS-rG(N-ibu)Phosphoramidite
• 5'-O-DMT-2'-TBDMS-rG(N-iBu)-3'-CEDPA
• i-bu-rG Phosphoramidite
• N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine-3'-cyanoethyl Phosphoramidite

Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

CAS: 147201-04-5

Formula: C₅₀H₆₈N₇O₉PSi

Purity: 96%

Color and Shape: Solid

Molecular weight: 970.1757

Ref: IN-DA001EOK

I-Bu-Rg Phosphoramidite

CAS: 147201-04-5

I-Bu-Rg Phosphoramidite

Purity: 98%

Molecular weight: 970.18g/mol

Ref: 54-OR1013561

2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine 3'-CE phosphoramidite

CAS: 147201-04-5

The 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-N2-isobutyrylguanosine 3'-CE phosphoramidite is an oligomer with a modified nucleoside. The modification of the nucleoside has been shown to be more efficient than other modifications, such as fluorine or bromine substitutions. This product is used in the synthesis of DNA and RNA oligomers. The coupling efficiency is high and can be used for ligand binding studies.

Formula: C₅₀H₆₈N₇O₉PSi

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 970.18 g/mol

Ref: 3D-PB08938

I-bu-rG Phosphoramidite

CAS: 147201-04-5

Purity: 96%

Molecular weight: 969.46

Ref: 10-F556391