CAS 147221-93-0: Delavirdine mesylate

Description: Delavirdine mesylate is a non-nucleoside reverse transcriptase inhibitor (NNRTI) primarily used in the treatment of HIV infection. It functions by binding to the reverse transcriptase enzyme, thereby inhibiting the replication of the virus. This compound is characterized by its chemical structure, which includes a pyridine ring and a substituted phenyl group, contributing to its pharmacological activity. Delavirdine mesylate is typically administered orally and is known for its relatively short half-life, necessitating multiple daily doses for effective viral suppression. It exhibits a moderate bioavailability and is metabolized primarily by the liver, with interactions noted with various cytochrome P450 enzymes. Common side effects may include rash, gastrointestinal disturbances, and potential liver enzyme elevations. Due to its specific mechanism of action, it is often used in combination with other antiretroviral agents to enhance therapeutic efficacy and reduce the risk of resistance development. Overall, Delavirdine mesylate plays a significant role in the management of HIV, contributing to improved patient outcomes when used appropriately.

Formula: C₂₂H₂₈N₆O₃S·CH₄O₃S

InChI: InChI=1S/C22H28N6O3S.CH4O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20;1-5(2,3)4/h4-8,13-15,24-26H,9-12H2,1-3H3;1H3,(H,2,3,4)

InChI key: InChIKey=MEPNHSOMXMALDZ-UHFFFAOYSA-N

SMILES: O=C(C1=CC=2C=C(C=CC2N1)NS(=O)(=O)C)N3CCN(C4=NC=CC=C4NC(C)C)CC3.O=S(=O)(O)C

Synonyms:

• Delavirdine methane sulfonate
• Methanesulfonamide, N-[2-[[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-, methanesulfonate (1:1)
• N-[2-({4-[3-(propan-2-ylamino)pyridin-2-yl]piperazin-1-yl}carbonyl)-1H-indol-5-yl]methanesulfonamide methanesulfonate (1:1)
• Piperazine, 1-[3-[(1-methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-, monomethanesulfonate
• Rescripta
• Rescriptor
• U 90152E
• U 90152S
• U 90152T
• Delavirdine mesylate

Methanesulfonamide, N-[2-[[4-[3-[(1-methylethyl)amino]-2-pyridinyl]-1-piperazinyl]carbonyl]-1H-indol-5-yl]-, methanesulfonate (1:1)

CAS: 147221-93-0

• Formula: C₂₃H₃₂N₆O₆S₂
• Purity: %
• Color and Shape: Solid
• Molecular weight: 552.6668

Delavirdine mesylate

CAS: 147221-93-0

• Formula: C₂₂H₂₈N₆O₃S·CH₃SO₃H
• Molecular weight: 552.67

Delavirdine mesylate

CAS: 147221-93-0

• Purity: ≥98%
• Molecular weight: 552.67g/mol

N-(2-(4-(3-(Isopropylamino)Pyridin-2-yl)Piperazine-1-Carbonyl)-1H-Indol-5-yl)Methanesulfonamide Methanesulfonate

CAS: 147221-93-0

• Purity: 99%+
• Molecular weight: 552.67g/mol

Delavirdine mesylate

CAS: 147221-93-0

Delavirdine mesylate (BHAP-U 90152 (mesylate)) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).

• Formula: C₂₃H₃₂N₆O₆S₂
• Purity: 99.99%
• Color and Shape: Light Brown Solid
• Molecular weight: 552.67

Delavirdine Mesylate

CAS: 147221-93-0

Applications A bisheteroarylpiperazine (BHAP) reverse transcriptase inhibitor. References Dueweke, T.J., et al.: Antimicrob. Ag. Chemother., …

• Formula: C₂₂H₂₈N₆O₃S·CH₄O₃S
• Color and Shape: Neat
• Molecular weight: 552.67

Delavirdine mesylate

CAS: 147221-93-0

Non-nucleoside reverse transcriptase inhibitor; antiviral agent against HIV

• Formula: C₂₃H₃₂N₆O₆S₂
• Purity: Min. 95%
• Color and Shape: White To Yellow Solid
• Molecular weight: 552.18248