CAS 147254-64-6

Ranirestat

Description:

Ranirestat is a chemical compound primarily studied for its potential therapeutic applications, particularly in the treatment of diabetic complications. It functions as an aldose reductase inhibitor, which means it inhibits the enzyme responsible for converting glucose into sorbitol, thereby potentially reducing the accumulation of sorbitol in tissues and mitigating osmotic and oxidative stress associated with diabetes. The molecular structure of Ranirestat includes specific functional groups that contribute to its biological activity and solubility properties. It is typically administered in a pharmaceutical formulation, and its efficacy and safety profile have been evaluated in various clinical studies. As with many pharmacological agents, the characteristics of Ranirestat, including its pharmacokinetics, metabolism, and potential side effects, are crucial for understanding its role in medical applications. Overall, Ranirestat represents a significant area of research in the context of managing diabetic complications and improving patient outcomes.

Formula: C₁₇H₁₁BrFN₃O₄

InChI: InChI=1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1

InChI key: InChIKey=QCVNMNYRNIMDKV-QGZVFWFLSA-N

SMILES: O=C1[C@@]2(N3C(C(=O)N1CC4=C(F)C=C(Br)C=C4)=CC=C3)CC(=O)NC2=O

Synonyms:

• (3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[pyrrolidine-3,4'-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone
• (3R)-2′-(4-Bromo-2-fluorobenzyl)-1′,2′,3′,4′-tetrahydrospiro[pyrrolidine-3,4′-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5-tetraone
• (3R)-2′-(4-Bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4′-1′H-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5(2′H)-tetraone
• (3R)-2′-[(4-Bromo-2-fluorophenyl)methyl]spiro[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5(2′H)-tetrone
• As-3201
• Ranirestat
• SX-3030(racemate)
• SX-3202((+)-(S)-isomer)
• Spiro[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5(2′H)-tetrone, 2′-[(4-bromo-2-fluorophenyl)methyl]-, (-)-
• Spiro[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5(2′H)-tetrone, 2′-[(4-bromo-2-fluorophenyl)methyl]-, (3R)-
• Sx-3201

Ranirestat

CAS: 147254-64-6

Ranirestat

Purity: ≥95%

Molecular weight: 420.19g/mol

Ref: 54-BUP17572

Ranirestat

Controlled Product

CAS: 147254-64-6

Formula: C₁₇H₁₁BrFN₃O₄

Color and Shape: Neat

Molecular weight: 420.189

Ref: TR-R119950

Ranirestat

CAS: 147254-64-6

Ranirestat (AS-3201) is an AR inhibitor with neuroprotective properties that improves peripheral nerve dysfunction in rats with advanced diabetic polyneuropathy

Formula: C₁₇H₁₁BrFN₃O₄

Purity: 96.10% - 99.44%

Color and Shape: Solid

Molecular weight: 420.19

Ref: TM-T16723