CAS 14729-29-4

Roridin A

Description:

Roridin A is a mycotoxin produced by certain species of fungi, particularly those in the genus *Fusarium*. It is classified as a macrocyclic trichothecene, a group of compounds known for their potent biological activity and toxicity. Roridin A exhibits a complex molecular structure characterized by a multi-ring system, which contributes to its stability and interaction with biological systems. This compound is primarily known for its ability to inhibit protein synthesis, leading to cytotoxic effects in various cell types. It has been studied for its potential effects on human health, particularly in relation to its immunosuppressive properties and its role in food contamination. Roridin A is also of interest in research concerning its mechanisms of action and potential applications in pharmacology, although its toxicity limits its use. Due to its hazardous nature, handling Roridin A requires strict safety precautions to prevent exposure.

Formula: C₂₉H₄₀O₉

InChI: InChI=1S/C29H40O9/c1-17-9-11-28-15-35-26(33)25(32)18(2)10-12-34-20(19(3)30)7-5-6-8-24(31)38-21-14-23(37-22(28)13-17)29(16-36-29)27(21,28)4/h5-8,13,18-23,25,30,32H,9-12,14-16H2,1-4H3/b7-5+,8-6+/t18-,19-,20-,21-,22-,23-,25+,27-,28-,29+/m1/s1

InChI key: InChIKey=NSFWWJIQIKBZMJ-LOSHTCFGSA-N

SMILES: C[C@@]12[C@@]3([C@]4(C[C@]1(OC(=O)/C=C/C=C/[C@]([C@@H](C)O)(OCC[C@@H](C)[C@H](O)C(=O)OC[C@]25[C@](O4)(C=C(C)CC5)[H])[H])[H])[H])CO3

Synonyms:

• (10Z,12Z)-4-hydroxy-9-(1-hydroxyethyl)-5,16a,21-trimethyl-4,5,6,7,16,16a,22,23-octahydro-3H,18H,19aH-spiro[16,18-methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene-17,2'-oxirane]-3,14(9H)-dione
• (4S,5R,9R,10E,12Z,16R,16aS,18R,19aR,23aR)-4-hydroxy-9-[(1R)-1-hydroxyethyl]-5,16a,21-trimethyl-4,5,6,7,16,16a,22,23-octahydro-3H,18H,19aH-spiro[16,18-methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene-17,2'-oxirane]-3,14(9H)-dione
• (4S,5R,9R,10Z,12Z,16R,16aS,17R,18R,19aR,23aR)-4-hydroxy-9-[(1R)-1-hydroxyethyl]-5,16a,21-trimethyl-4,5,6,7,16,16a,22,23-octahydro-3H,18H,19aH-spiro[16,18-methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene-17,2'-oxirane]-3,14(9H)-dione
• (7′R)-7′-Deoxo-7′-[(1R)-1-hydroxyethyl]verrucarin A
• Ai3-29708
• Nsc 200737
• Roridan A
• Roridin A
• Roridine A
• Spiro[16,18-methano-1H,3H,23H-[1,6,12]trioxacyclooctadecino[3,4-d][1]benzopyran-17(18H),2′-oxirane], verrucarin A deriv.
• Verrucarin A, 7'-deoxo-7'-((1R)-1-hydroxyethyl)-, (7'R)-
• Verrucarin A, 7'-deoxo-7'-(1-hydroxyethyl)-
• Verrucarin A, 7'-deoxo-7'-(1-hydroxyethyl)-, (7'R(R))-
• Verrucarin A, 7′-deoxo-7′-(1-hydroxyethyl)-, [7′R(R)]-

Roridin A

CAS: 14729-29-4

Roridin A

Formula: C₂₉H₄₀O₉

Purity: By hplc: 99.22% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 532.62249g/mol

Ref: 54-BIR0141

Roridin A

CAS: 14729-29-4

Roridin A (Roridine A) is a compound isolated from the bacterium Verruca sp. and shows nematicidal activity against Meloidogyne incognita.

Formula: C₂₉H₄₀O₉

Color and Shape: Solid

Molecular weight: 532.62

Ref: TM-T125818

Roridin A

CAS: 14729-29-4

Roridin A is a trichothecene mycotoxin, a type of secondary metabolite produced by certain fungal species, primarily of the genus Myrothecium. The source of Roridin A is natural, derived from fungal cultures that synthesize this compound during their metabolic processes. Its mode of action involves the inhibition of protein synthesis. Roridin A specifically interacts with the ribosomal machinery of eukaryotic cells, leading to impairment in protein elongation, ultimately causing cytotoxic effects.

Formula: C₂₉H₄₀O₉

Purity: Min. 95%

Molecular weight: 532.62 g/mol

Ref: 3D-FR171536

Roridin A

CAS: 14729-29-4

Formula: C₂₉H₄₀O₉

Molecular weight: 532.63

Ref: 4Z-R-113001