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CAS 147490-49-1

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AMYLOID BETA-PROTEIN (25-35) AMIDE

Description:
Amyloid beta-protein (25-35) amide, with the CAS number 147490-49-1, is a peptide fragment derived from the amyloid precursor protein (APP). This specific fragment consists of 11 amino acids and is known for its role in the formation of amyloid plaques, which are characteristic of Alzheimer's disease. The peptide is typically hydrophobic, which contributes to its aggregation properties, leading to the formation of oligomers and fibrils that are toxic to neurons. Its structure includes a sequence that is crucial for its biological activity, particularly in neurotoxicity and synaptic dysfunction. The amide form indicates that the C-terminus of the peptide is amidated, which can enhance its stability and biological activity. Research on this peptide is significant for understanding the pathophysiology of Alzheimer's disease and developing potential therapeutic strategies. Additionally, it is often used in experimental studies to investigate the mechanisms of amyloid aggregation and its effects on neuronal cells.
Formula:C45H82N14O13S
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